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TH287

TH287 Struktur
1609960-30-6
CAS-Nr.
1609960-30-6
Englisch Name:
TH287
Synonyma:
TH287;CS-1671;Centicin;Septigen;TH287, >98%;TH287;TH-287;Oksitselanim;TH287 hydrochloride;6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine;6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine
CBNumber:
CB82749064
Summenformel:
C11H10Cl2N4
Molgewicht:
269.13
MOL-Datei:
1609960-30-6.mol

TH287 Eigenschaften

Siedepunkt:
512.2±60.0 °C(Predicted)
Dichte
1.440±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: soluble5mg/mL, clear (warmed)
pka
5.91±0.10(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22-41
S-S?tze: 26-39
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H318 Verursacht schwere Augensch?den. Schwere Augensch?digung Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS05.jpg" width="20" height="20" /> P280, P305+P351+P338, P310
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

TH287 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH287 is an MTH1 inhibitor (IC50 = 0.8 nM) that selectively kills cancer cell lines (IC50s = 0.8-3.06 μM) without significant cytotoxicity towards primary or immortalized cells (IC50s = ≥20 μM). At up to 100 μM it does not show significant effect towards the related nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, as well as other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase, and ITPA).

Verwenden

6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine is known to possess antitumor effects and nanomolar MTH1-inhibitory activity in vitro for cancer cell survival.

TH287 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

2,3-Dichlorophenylboronic acid NSC36831 4-chloro-6-(2,3-dichlorophenyl)pyrimidin-2-amine Methylamin, gasf?rmig

Downstream Produkte

TH287 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 98)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29880 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Coresyn Pharmatech Co., Ltd. 		+86-571-86626709 +86-18157142896
 cbc@coresyn.com China 9984 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998
 757984502@qq.com China 892 58
  • TH287 hydrochloride
  • TH287
  • 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine
  • 6-(2,3-Dichlorophenyl)-N4-methylpyrimidine-2,4-diamine hydrochloride
  • 6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine
  • TH287;TH-287
  • CS-1671
  • TH287, >98%
  • 2,4-Pyrimidinediamine, 6-(2,3-dichlorophenyl)-N4-methyl-
  • 6-(2,3-Dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine
  • Centicin
  • Oksitselanim
  • Septigen
  • 6-(2,3-Dichlorophenyl)-N4-methylpyrimidine-2,4-diamine , TH287
  • 1609960-30-6
  • Inhibitors
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