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Morinidazole

Morinidazole Struktur
92478-27-8
CAS-Nr.
92478-27-8
Englisch Name:
Morinidazole
Synonyma:
Morinidazole;Morpholinenidazole impurity H;1-(2-methyl-5-nitro-1H-imidazol-1-yl)-3-morpholinopropan-2-ol;4-Morpholineethanol, α-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-;alpha-[(2-Methyl-5-nitro-1H-imidazol-1-yl)methyl]-4-morpholineethanol
CBNumber:
CB82716291
Summenformel:
C11H18N4O4
Molgewicht:
270.29
MOL-Datei:
92478-27-8.mol

Morinidazole Eigenschaften

Siedepunkt:
521.4±50.0 °C(Predicted)
Dichte
1.44±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO : ≥ 100 mg/mL (369.97 mM)
pka
14.14±0.20(Predicted)
Aggregatzustand
Solid
Farbe
White to off-white

Sicherheit

Morinidazole Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Morinidazole (邁靈達(dá)®), discovered and developed by Jiangsu Hansoh Pharmaceutical, was approved by the CFDA in February 2014. Morinidazole is a novel third generation 5-nitroimidazoleclass antimicrobial agent indicated for the treatment of amoebiasis and anaerobic bacterial infections including appendicitis and pelvic inflammatory disease. 5-Nitroimidazole antimicrobial drugs act via nitroreduction of the molecules in the pathogens; as an analog of metronidazole, morinidazole exhibits greater antiparasitic potency against Trichomonas vaginalis and amoebic protozoa, and relatively weaker toxicity in vitro and in preclinical studies compared with metronidazole.

Synthese

The strategy to prepare morinidazole, which exists as a racemate, overlaps with that of ornidazole. Commercially available epichlorohydrin (176) was reacted with commercial 2-methyl-5-nitro-1H-imidazole (175) to provide ornidazole 177 in 51% yield. Next, epoxide 178 was obtained in 84% through the treatment of ornidazole 177 with TBAF in aqueous sodium hydroxide. Subsequently, the ring of epoxide 178 was opened with the treatment of morpholine (179) to afford morinidazole (XX) in 75% yield.

Synthesis_92478-27-8

Morinidazole Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Morinidazole Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 67)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd.
+86-029-86185165 +8618629664246
guoyuan@eastchinapharm.com China 1615 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152
Mandy@hangyubiotech.com China 10986 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Moxin Chemicals
+8617320513646
mike@molcoo.com China 9457 58
QUALITY CONTROL SOLUTIONS LTD.
0755-66853366; 13670046396
ORDERS@QCSRM.COM China 24342 58
FarmaSino Pharmaceuticals (Jiangsu) Co.,Ltd 25-8690-7345 18651693585
zfx@farmasino.com China 129 58
Haoyuan Chemexpress Co., Ltd. 021-58950125
info@chemexpress.com China 7552 61
MedChemexpress LLC 021-58955995
sales@medchemexpress.cn United States 4861 58

  • Morinidazole
  • alpha-[(2-Methyl-5-nitro-1H-imidazol-1-yl)methyl]-4-morpholineethanol
  • 4-Morpholineethanol, α-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-
  • 1-(2-methyl-5-nitro-1H-imidazol-1-yl)-3-morpholinopropan-2-ol
  • Morpholinenidazole impurity H
  • 92478-27-8
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