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Prilocain

Prilocaine Struktur
721-50-6
CAS-Nr.
721-50-6
Bezeichnung:
Prilocain
Englisch Name:
Prilocaine
Synonyma:
PRILOCAINE BASE;Aβ25-35;Citanest;Propitocaine;l67;N-(2-methylphenyl)-2-(propylamino)propionamide;L 67;Priloca;astra1512;astra1515
CBNumber:
CB8270843
Summenformel:
C13H20N2O
Molgewicht:
220.31
MOL-Datei:
721-50-6.mol

Prilocain Eigenschaften

Schmelzpunkt:
37-38°
Siedepunkt:
bp0.1 159-162°
Dichte
1.0117 (rough estimate)
Brechungsindex
nD20 1.5298
storage temp. 
2-8°C
L?slichkeit
Slightly soluble in water, very soluble in acetone and in ethanol (96 per cent).
pka
pKa 7.32 or 7.89 (Uncertain)
Aggregatzustand
Solid
Farbe
White to off-white
Wasserl?slichkeit
6.169g/L(25 ºC)
InChI
InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16)
InChIKey
MVFGUOIZUNYYSO-UHFFFAOYSA-N
SMILES
C(NC1=CC=CC=C1C)(=O)C(NCCC)C
CAS Datenbank
721-50-6(CAS DataBase Reference)
NIST chemische Informationen
Propanamide, n-(2-methylphenyl)-2-(propylamino)-(721-50-6)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  2924296000
Giftige Stoffe Daten 721-50-6(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Prilocain Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White or almost white, crystalline powder.

Verwenden

Prilocaine is a local anesthetic of the amino amide type. Prilocaine is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia.

Definition

ChEBI: An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.

Trademarks

lidocaine/prilocaine topical
Brand names: Emla, LiproZonePak, Dolotranz, Livixil Pak, and Anodyne LPT.

Allgemeine Beschreibung

Prilocaine hydrochloride is a water-soluble salt available asa solution for nerve block or infiltration in dental procedures.Prilocaine is used for intravenous regional anesthesiaas the risk of CNS toxicity is low because of the quick metabolism.Prilocaine prepared in the crystal form is used inEMLA for topical administration to decrease painful needlesticks in children. Prilocaine 4% solution should be protectedfrom light and the manufacturer recommends discardingif the solution turns pinkish or slightly darker than lightyellow. Solutions are available in various concentrations upto 4%, with or without epinephrine and with or withoutpreservatives.

Pharmakologie

Prilocaine is less toxic than lidocaine, with a high clearance, attributable to metabolism in the lungs, kidneys and liver. It is associated with methaemoglobinaemia at doses >600mg. It is sometimes used at a concentration of 0.5% for the provision of intravenous regional anaesthesia, and a combination of prilocaine 3% with felypressin is available for low-volume local infiltration anaesthesia in dental surgery. A 2% formulation is also available for spinal anaesthesia. Prilocaine is also formulated in a eutectic mixture with lidocaine (EMLA) for topical anaesthesia.

Clinical Use

Prilocaine metabolism has beenstudied extensively in animal models, less is known aboutthe human metabolites or the human CYP enzymes involvedin their formation . The metabolism of prilocainein the liver yields o-toluidine, which is a possiblecarcinogen. Many aromatic amines, including o-toluidinehave been shown to be mutagenic, and metabolites of otoluidinehave been shown to form DNA adducts.Metabolites of o-toluidine are also believed to be responsiblefor the methemoglobinemia observed with prilocaineuse. To decrease the potential for methemoglobinemia, strictadherence to the maximum recommended dose should befollowed. Metabolism of prilocaine is extensive with lessthan 5% of a dose excreted unchanged in the urine.

Prilocain Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Prilocain Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 430)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616
gksales1@gk-bio.com China 9312 58
Wuhan Aoliqisi New Material Technology Co., Ltd.
+86-13545906766; +8613545906766
sales@whaop.com China 263 58
Hebei Miaoyin Technology Co.,Ltd
+86-17367732028 +86-17367732028
kathy@hbyinsheng.com China 3512 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Guangzhou Tosun Pharmaceutical Ltd
+86-020-61855200-902 +8618124244216
info@upharm.cn China 835 58
Dorne Chemical Technology co. LTD
+86-86-13583358881 +8618560316533
Ethan@dornechem.com China 3096 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Firsky International Trade (Wuhan) Co., Ltd
+8615387054039
admin@firsky-cn.com China 427 58
Anhui Yiao New Material Technology Co., Ltd
+86-18033737140 +86-17354101231
sales1@hbganmiao.com China 227 58
shandong perfect biotechnology co.ltd
+86-53169958659 +86-13153181156
sales@sdperfect.com China 294 58

721-50-6(Prilocain)Verwandte Suche:


  • astra1512
  • o-Propionotoluidide, 2-(propylamino)- (6CI, 8CI)
  • Propanamide, N-(2-methylphenyl)-2-(propylamino)- (9CI)
  • Prilocaine (200 mg)
  • 2-(PropylaMino)-N-(o-tolyl)propanaMide
  • Prilocaine HCl (base)
  • Prilocaine N-(2-Methylphenyl)-2-propylamino-propanamide
  • (±)-2′-Methyl-2-(propylamino)propionanilide
  • PRILOCAINE USP API
  • 2-(propylamino)-o-propionotoluidid
  • 2-(Propylamino)-o-propionotoluidide
  • 2-Methyl-alpha-propylaminopropionanilide
  • alpha-n-Propyl-amino-2-methylpropionanilide
  • alpha-n-propylamino-2-methylpropionanilide
  • Astra 1512
  • Astra 1515
  • PRILOCAINE
  • n-(2-methylphenyl)-2-propylamino-propanamide
  • astra1515
  • L 67
  • n-(2-methylphenyl)-2-(propylamino)-propanamid
  • o-Methyl-2-propylaminopropionanilide
  • o-Methyl-alpha-propylaminopropionanilide
  • o-Propionotoluidide, 2-(propylamino)-
  • o-Propionotuluidide, 2-propylamino-
  • Propanamide, N-(2-methylphenyl)-2-(propylamino)-
  • (+-)-N-(2-Propylaminopropionyl)-2-toluidine
  • 2-Methyl-a-propylaminopropionanilide
  • DL-(+-)-Prilocaine
  • N-(2,6-Dimethylphenyl)-2-(propylamino)propanamide
  • NSC 40027
  • 2-(propylamino)propion-o-toluidide
  • PRILOCAINE EPP
  • PRILOCAINE EPP(CRM STANDARD)
  • PRILOCAINE HCL USP
  • Prilocaine USP/EP/BP
  • Prilocaine 13C D3
  • European Market, Prilocaine Powder for Relieving Pain Prilocaine Price 721-50-6
  • Prilocaine (1560990)
  • β-Amyloid peptide(25-35)
  • IN STOCK PRILOCAINE BASE CAS NO.721-50-6
  • PRILOCAINE BASE CAS NO.721-50-6
  • Prilocaine Cas number:(721-50-6)
  • Anesthesia Mepivacaine CAS NO. 721-50-6
  • N1-(2-methylphenyl)-N2-propylalaninamide
  • Prilocaine, >96%
  • prilocaine pure
  • Bulk Supply Prilocaine
  • Priloca
  • Prilocainc
  • N-(2-methylphenyl)-2-(propylamino)propionamide
  • PRILOCAINE BASE
  • Citanest
  • l67
  • Propitocaine
  • Aβ25-35
  • Prilocaine CAS721-50-6
  • Prilocain
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