UNC2250
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- CAS-Nr.
- 1493694-70-4
- Englisch Name:
- UNC2250
- Synonyma:
- CS-1346;UNC2250;UNC2250 USP/EP/BP;UNC2250(UNC 2250);UNC2250, 10 mM in DMSO;trans-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol;4-[[2-(butylamino)-5-[5-(morpholin-4-ylmethyl)pyridin-2-yl]pyrimidin-4-yl]amino]cyclohexan-1-ol;(1r,4r)-4-((2-(butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol;trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanol;Cyclohexanol, 4-[[2-(butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]-, trans-
- CBNumber:
- CB82677545
- Summenformel:
- C24H36N6O2
- Molgewicht:
- 440.58
- MOL-Datei:
- 1493694-70-4.mol
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UNC2250 Eigenschaften
- Schmelzpunkt:
- 207-210oC
- Siedepunkt:
- 657.4±65.0 °C(Predicted)
- Dichte
- 1.224±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator, under inert atmosphere
- L?slichkeit
- Chloroform (Slightly, Heated), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 15.02±0.40(Predicted)
- Farbe
- Pale Yellow to Yellow
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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UNC2250 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Tyro3, Axl, and Mer are members of the TAM family of receptor tyrosine kinases that have signaling roles in normal and malignant cells. UNC2250 is an inhibitor of Mer kinase activity, blocking the steady-state phosphorylation of endogenous Mer in 697 B-ALL cells with an IC
50 value of 9.8 nM. It is selective for Mer over a panel of both tyrosine and serine-threonine kinases, including Tyro3 and Axl. UNC2250 also inhibits ligand-dependent phosphorylation of a chimeric EGFR-Mer protein and blocks colony formation in soft agar cultures of BT-12 rhabdoid tumor and Colo699 NSCLC cell lines. UNC2250 displays good pharmacokinetic properties in mice following intravenous or oral administration.
UNC2250 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
UNC2250 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 88)Lieferanten
- (1r,4r)-4-((2-(butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol
- UNC2250
- trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanol
- trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanol UNC2250
- CS-1346
- UNC2250(UNC 2250)
- 4-[[2-(butylamino)-5-[5-(morpholin-4-ylmethyl)pyridin-2-yl]pyrimidin-4-yl]amino]cyclohexan-1-ol
- Cyclohexanol, 4-[[2-(butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]-, trans-
- UNC2250 USP/EP/BP
- trans-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol
- UNC2250, 10 mM in DMSO
- 1493694-70-4
- C24H36N6O2
- Inhibitors
