GDC-0834 Chemische Eigenschaften,Einsatz,Produktion Methoden

Biologische Aktivit?t

GDC-0834 is a potent and selective Bruton's tyrosine kinase (Btk) inhibitor, The IC50 values in biochemical and cellular assays is 5.9 and 6.4 nM. The in vivo IC50 values in mouse and rat are 1.1 and 5.6 μM, respectively. B cell antigen receptor (BCR) stimulation phosphorylated and activated Btk. Btk gene defects result in a disease named as X-linked agammaglobulinemia which profoundly decreased mature B cells due to a block in B cell development.

GDC-0834 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

GDC-0834 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32080	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38470	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52925	58
TargetMol Chemicals Inc.	+8613564774135	zijue.cai@tsbiochem.com	United States	19863	58
Jinan Trio PharmaTech Co., Ltd.	+86 (531) 88811783	sales@trio-pharmatech.com (International market)	China	1856	62
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4861	58
Musechem	+1-800-259-7612	info@musechem.com	United States	4660	60
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11217	58
Absin Bioscience Inc.	021-38015121 15000105423	wulan@absin.cn	China	24731	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8140	58

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• GDC-0834 (S-enantiomer)
• Benzo[b]thiophene-2-carboxamide, N-[3-[6-[[4-[(2S)-1,4-dimethyl-3-oxo-2-piperazinyl]phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]-4,5,6,7-tetrahydro-
• GDC 0834 S enantiomer,GDC0834 Senantiomer
• 1133432-50-4