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GZD 824

GZD 824 Struktur
1257628-77-5
CAS-Nr.
1257628-77-5
Englisch Name:
GZD 824
Synonyma:
GZD824;GZD8824;GZD-824;GZD 824;GZD-824 Free;Olverembatinib;GZD 824 USP/EP/BP;GZD824;GZD-824;GZD 824;Olverembatinib (GZD824);GZD-824; GZD 824;BENZAMIDE
CBNumber:
CB82666626
Summenformel:
C29H27F3N6O
Molgewicht:
532.56
MOL-Datei:
1257628-77-5.mol

GZD 824 Eigenschaften

Siedepunkt:
630.4±55.0 °C(Predicted)
Dichte
1.39±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO : ≥ 100 mg/mL (187.77 mM)
Aggregatzustand
A crystalline solid
pka
9.04±0.40(Predicted)
Farbe
Off-white to yellow

Sicherheit

GZD 824 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

GZD-824 is an orally available inhibitor of a broad spectrum of Bcr/Abl tyrosine kinase mutants including T315I (IC50s = 0.34 and 0.68 nM for wild-type Bcr/Abl and Bcr/AblT315I, respectively). It has been shown to suppress the proliferation of Bcr/Abl-positive K562 and Ku812 human chronic myelogenous leukemia cells (IC50s = 0.2 and 0.13 nM, respectively) and induce tumor regression in mouse xenograft tumor models driven by either wild-type or mutant Bcr/Abl.

Verwenden

GZD824 is a orally bioavailable inhibitor that targets phosphorylated and non-phosphorylated Breakpoint Cluster Region-Abelson (Bcr-Abl) kinases. It is a COVID19-related research product.

target

BCR-ABL

GZD 824 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

1H-Pyrazolo[3,4-b]pyridine, 5-[2-(trimethylsilyl)ethynyl]- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline 5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE 4-b]pyridine METHYL 3-IODO-4-METHYLBENZOATE

Downstream Produkte

GZD 824 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 105)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070
product@chemlin.com.cn CHINA 3009 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32965 60
TianYuan Pharmaceutical CO.,LTD 		+86-755-23284190 13684996853
sales@tianpharm.com CHINA 304 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28172 58
Accela ChemBio Inc. 		+1-858-6993322
info@accelachem.com United States 18568 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30233 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 22787 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894
 shawn@hirisunpharm.com CHINA 9911 58
  • 4-Methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide
  • 3-(2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
  • GZD8824
  • GZD824;GZD-824;GZD 824
  • GZD-824 Free
  • GZD 824
  • GZD824
  • GZD-824
  • GZD-824; GZD 824;BENZAMIDE
  • Benzamide, 4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]-
  • GZD 824 USP/EP/BP
  • 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
  • Olverembatinib
  • Olverembatinib (GZD824)
  • 3-[(1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl]-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide
  • 4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-(2-{1H-pyrazolo[3,4-b]pyridin-5-yl}ethynyl)benzamide
  • Olverembatinib, 10 mM in DMSO
  • 1257628-77-5
  • 257628-77-5
  • Inhibitors
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