Edoxaban tosylate monohydrate
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- CAS-Nr.
- 1229194-11-9
- Englisch Name:
- Edoxaban tosylate monohydrate
- Synonyma:
- Edoxaban tosilate;edoxaban tosylate hydrate;Edoxaban Tosilate Monohydrate;Lixiana;Ethanediamide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonate, hydrate;CS-1597;Yidu Saban Mesylate;Etoxaban methanesulfonate;Edoxaban Tosylate Hydrate 1;Etuxaban p-toluenesulfonate
- CBNumber:
- CB82645582
- Summenformel:
- C31H38ClN7O7S2
- Molgewicht:
- 720.26
- MOL-Datei:
- 1229194-11-9.mol
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Edoxaban tosylate monohydrate Eigenschaften
- Schmelzpunkt:
- >252°C (dec.)
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- L?slichkeit
- Chloroform (Very Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Stabilit?t:
- Hygroscopic
- InChIKey
- ZLFZITWZOYXXAW-BUZWFPPCNA-N
- SMILES
- S(C1C=CC(C)=CC=1)(O)(=O)=O.N([C@@H]1C[C@@H](C(=O)N(C)C)CC[C@@H]1NC(=O)C(=O)NC1N=CC(Cl)=CC=1)C(C1SC2CN(C)CCC=2N=1)=O |&1:12,14,22,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Edoxaban tosylate monohydrate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Edoxaban tosylate monohydrate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase.
Edoxaban monohydrate exhibits more than 10,000-fold selectivity over
other coagulation proteases. Edoxaban monohydrate can be used for
preventing thromboembolic disease research.
Verwenden
Edoxaban is an anticoagulant drug which acts as a direct factor Xa inhibitor.
Definition
ChEBI: A hydrate that is the monohydrate of the tosylate salt of edoxaban. Used for the treatment of deep vein thrombosis and pulmonary embolism.
Clinical Use
Daichi Sankyo’s edoxaban tosilate is an orally administered
coagulation factor Xa inhibitor that was approved and launched
in Japan for the preventive treatment of venous thromboembolic
events (VTE) in patients undergoing total knee arthroplasty, total
hip arthroplasty, or hip fracture surgery. Edoxaban has been
shown to have a rapid onset of anticoagulant effect due to short
Tmax (1–2 h) after dosing and sustained for up to 24 h post-dose.
Marketed under the brand name Lixiana, it is currently in phase
III studies in the US for the prevention of stroke and systemic embolic
events in patients with atrial fibrillation (AF) and venous
thromboembolism (VTE).
Edoxaban tosylate monohydrate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Edoxaban tosylate monohydrate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 261)Lieferanten
1229194-11-9()Verwandte Suche:
- Edoxaban (tosylate Monohydrate)
- Edoxaban p-toluenesulfonate monohydrate
- N-(5-Chloropyridin-2-yl)-N'-((1S,2R,4S)-4-[(dimethyl amino)carbonyl]-2-[[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl)ethanediamide p-toluenesulfonate monohydrate
- N1-(5-Chloropyridin-2-yl)-N2-((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide 4-methylbenzenesulfonate hydrate
- Edoxaban Tosylate Hydrate 1
- Edoxaban (TsOH salt hydrate)
- CS-1597
- Edoxaban tosylate monohydrate(for Edoxaban)
- DU-176b tosylate Monohydrate
- Edoxaban (tosylate Monohydrate) USP/EP/BP
- Edoxaban tosylate monohydrate (DU-176b)
- Edoxaban tosilate
- Ethanediamide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonate, hydrate
- edoxaban tosylate hydrate
- Edoxaban Tosilate Monohydrate
- Lixiana
- Idoseban p-Toluenesulfonate Monohydrate
- Etuxaban p-toluenesulfonate
- Yidu Saban Mesylate
- Edoxaban Impurity 34 p-Toluenesulfonate Salt Monohydrate
- Edoxaban Impurity 29 p-Toluenesulfonate Salt
- Edoxaban Tosylate Monohydrate, 10 mM in DMSO
- Etoxaban methanesulfonate
- Etoxaban p-toluenesulfonic acid
- 1229194-11-9
- C24H30ClN7O4SC7H8O3SH2O
- C31H40ClN7O8S2
- Inhibitors
- API
