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3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole

3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole Struktur
395104-30-0
CAS-Nr.
395104-30-0
Englisch Name:
3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole
Synonyma:
CC-401;CS-400;JNK-401);CC-401 (HCl);CC-401, >=98%;CC-401 (CC401;3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole;1-[5-(1H-1,2,4-Triazol-5-yl)-1H-indazol-3-yl]-3-(2-piperidinoethoxy)benzene;3-(3-(2-(Piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-5-yl)-1H-indazole;3-(3-(2-(piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-3-yl)-1H-indazole
CBNumber:
CB82484877
Summenformel:
C22H24N6O
Molgewicht:
388.47
MOL-Datei:
395104-30-0.mol

3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole Eigenschaften

Siedepunkt:
681.5±65.0 °C(Predicted)
Dichte
1.275
storage temp. 
Store at -20°C
L?slichkeit
≥19.4 mg/mL in DMSO; ≥2.32 mg/mL in EtOH with ultrasonic; ≥8.7 mg/mL in H2O
Aggregatzustand
solid
pka
9.44±0.20(Predicted)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  2933399990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

c-Jun N-terminal kinases (JNKs) are MAP kinase family members that become highly activated after cells are exposed to stress conditions and are poorly activated by exposure to growth factors or mitogens. CC-401 is a potent inhibitor of all three JNK isoforms (Ki values range from 25 to 50 nM). It has at least 40-fold selectivity for JNK compared with other related kinases. CC-401 is bioavailable when delivered by gavage, blocking JNK signaling and renal fibrosis in a rat obstructed kidney model. It also has been shown to decrease hepatic necrosis and apoptosis after orthotopic liver transplantation and prevent acute renal failure following ischemia/reperfusion associated with renal transplantation in rats.

Verwenden

CC-401 inhibits c-JUN N-terminal kinases (JNKs) by binding to its ATP-binding site. JNKs belong to the MAP kinase family and respond to stress signals such as heat, cytokines, and osmotic shock.

3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole Upstream-Materialien And Downstream Produkte

Upstream-Materialien

1H-Indazole-5-carboxamide, 3-[3-[2-(1-piperidinyl)ethoxy]phenyl]- 1,1-Dimethoxytrimethylamin

Downstream Produkte

3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 85)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806
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CONIER CHEM AND PHARMA LIMITED 		+8618523575427
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
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InvivoChem 		+1-708-310-1919 +1-13798911105
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LEAPCHEM CO., LTD. 		+86-852-30606658
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Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652
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Aladdin Scientific 		+1-+1(833)-552-7181
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SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580
 cooperation@kean-chem.com China 40066 58
Amadis Chemical Company Limited 		571-89925085
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395104-30-0()Verwandte Suche:

  • 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole
  • CC-401
  • CC-401 (HCl)
  • 3-(3-(2-(piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-3-yl)-1H-indazole
  • CC4013-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole
  • CC-401, >=98%
  • 3-(3-(2-(Piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-5-yl)-1H-indazole
  • 1-[5-(1H-1,2,4-Triazol-5-yl)-1H-indazol-3-yl]-3-(2-piperidinoethoxy)benzene
  • CC-401 (CC401
  • JNK-401)
  • CS-400
  • 1H-Indazole, 3-[3-[2-(1-piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-
  • 395104-30-0
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