L-Homophenylalanin
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- CAS-Nr.
- 943-73-7
- Bezeichnung:
- L-Homophenylalanin
- Englisch Name:
- L-Homophe-OH
- Synonyma:
- HOMOPHENYLALANINE;(S)-2-AMINO-4-PHENYLBUTANOIC ACID;HPHE;LHPA;(S)-APBA;H-HPH-OH;H-HFE-OH;L-HPhe-OH;L-HOMOPHE;H-L-HPA-OH
- CBNumber:
- CB8206268
- Summenformel:
- C10H13NO2
- Molgewicht:
- 179.22
- MOL-Datei:
- 943-73-7.mol
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L-Homophenylalanin Eigenschaften
- Schmelzpunkt:
- >300 °C(lit.)
- alpha
- 45 º (C=1, 3N HCl 19 ºC)
- Siedepunkt:
- 311.75°C (rough estimate)
- Dichte
- 1.1248 (rough estimate)
- Brechungsindex
- 44 ° (C=1, 3mol/L HCl)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- L?slichkeit
- Soluble in dilute aqueous acid.
- Aggregatzustand
- Solid
- pka
- 2.32±0.10(Predicted)
- Farbe
- White to Off-White
- InChI
- InChI=1/C10H13NO2/c11-9(10(12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H,12,13)/t9-/s3
- InChIKey
- JTTHKOPSMAVJFE-VIFPVBQESA-N
- SMILES
- C(O)(=O)[C@H](CCC1=CC=CC=C1)N |&1:3,r|
- CAS Datenbank
- 943-73-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| S-S?tze: |
22-24/25 |
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| WGK Germany |
3 |
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| HS Code |
29224999 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H312 |
Gesundheitssch?dlich bei Hautkontakt. |
Akute Toxizit?t dermal |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P280,P302+P352, P312, P322, P363,P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H332 |
Gesundheitssch?dlich bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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L-Homophenylalanin Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
White Solid
Application
L-homophenylalanine is used almost exclusively as single stereoisomer in pharmaceutical drug production. L-homophenylalanine as a common building block, due to the presence of L-homophenylalanine moiety as the central pharmacophore unit. L-homophenylalanine is also an important chiral intermediate to synthesize a variety of novel pharmaceuticals including β-lactam antibiotics, acetylcholinesterase inhibitor and neutral endopeptidace (NEP) inhibitor which retained their status as major contributors to human health preservation. L-homophenylalanine acts as a precursor for the synthesis of NEP inhibitors, which complements the effects of ACE inhibitors when used simultaneously, potentiates the outcome in the management of hypertension and congestive heart failure[1].
Verwenden
L-Homophenylalanine is used as a precursor in the pharmaceutical industry for the production of angiotensin-converting enzyme (ACE) and R-(-)-Homophenylalanin-ethylester. It is also involved in the synthesis of NEPA [(S,S)-N-(1-Ethoxycarbonyl-3-phenylpropyl)alanine], which is a key intermediate to prepare the ACE-inhibitors: enalapril, delapril, quinapril and ramipril. It acts as an anti-tumor reagent.
Definition
ChEBI: A non-proteinogenic L-alpha-amino acid that is an analogue of L-phenylalanine having a 2-phenylethyl rather than a benzyl side-chain.
L-Homophenylalanin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
4-Morpholinecarboxylic acid, 2-oxo-3-(2-oxo-2-phenylethyl)-5,6-diphenyl-, phenylmethyl ester, (3S,5S,6R)-
2-acetamido-4-phenyl-butanoic acid
D-Homophenylalanine
(1R,2S)-2-Amino-1,2-diphenylethanol
Benzyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate
E-PHENYLETHENYLBORONIC ACID
N-[(1S,2R)-2-Hydroxy-1,2-diphenylethyl]-glycine Ethyl Ester
2-Oxo-4-phenylbuttersure
Downstream Produkte
L-Homophenylalanin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 548)Lieferanten
943-73-7(L-Homophenylalanin)Verwandte Suche:
- (+)-2-Amino-4-phenylbutyric acid,98%
- S)-α-Amino-benzenebutanoic acid
- L-(S)-Homophenylalanine.HCl
- L-Homophenylalanine ,98%
- H-L-HPA-OH
- Benzenebutanoicacid, a-aMino-, (aS)-
- H-HoMophe-OH(HoMophenylalanine)
- RARECHEM BK PT 0049
- (S)-(+)-2-AMINO-4-PHENYLBUTYRIC ACID
- (S)-2-AMINO-4-PHENYLBUTYRIC ACID
- (S)-HOMOPHENYLALANINE
- (2S)-2-Amino-4-phenylbutyric acid
- (S)-APBA
- (aS)-α-Aminobenzenebutanoic Acid
- L-Benzylalanine
- L--Phenylbutyrine
- (aS)-a-Aminobenzenebutanoic Acid
- L-HOMOPHENYLALANINE extrapure
- L-HPhe-OH
- Benzenebutanoic acid, alpha-amino-, (S)-
- Benzenebutanoic acid, .alpha.-amino-, (.alpha.S)-
- L-Homophe-OH
- (αS)-α-Amino-benzenebutanoic Acid,99%e.e.
- 2-(S)-AMINO-4-PHENYLBUTANOIC ACID
- L-ALPHA-AMINO-4-PHENYLBUTYRIC ACID
- L-2-AMINO-4-PHENYLBUTYRIC ACID
- L-HOMOPHE
- L-(+)-HOMOPHENYLALANINE
- L-HOMOPHENYLALANINE
- LHPA
- H-HPH-OH
- H-HOMOPHE-OH
- H-HOPHE-OH
- H-HFE-OH
- HOMO-L-PHENYLALANINE
- HOMOPHENYLALANINE, L-
- L- Homophenylalanine (LHPA)
- Homophenyl-L-alanine
- (+)-2-Amino-4-phenylbutyric acid
- H-L-HPhe-OH
- L-Homophenylalanine, (S)-2-Amino-4-phenyl-butyric acid
- L-Homophenylalanine99%
- L-Homophenylalanine 99%
- (2R)-2-amino-4-phenylbutanoic acid
- (S)-ALPHA-AMINOBENZENEBUTANOIC ACID
- TIANFUCHEM--943-73-7---L-Homophenylalanine
- L-Homophenylalanine USP/EP/BP
- -HomophenyL
- L-Homophenylalanine>
- (2S)-2-ammonio-4-cyclohexylbutanoate
- Boc-D-&beta
- Fmoc-4-nitro-L-&beta
- Benzenebutanoic acid, α-amino-, (αS)-
- HOMOPHENYLALANINE
- HPHE
- (S)-2-AMINO-4-PHENYLBUTANOIC ACID
- L-Homophenylalanine,97%
- (αS)?-α-?Amino-benzenebutanoic Acid
