Abacavir-d4 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Abacavir-d₄ is intended for use as an internal standard for the quantification of abacavir by GC- or LC-MS. Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (K_i = 2.1 μM for the wild-type enzyme). It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3''-azido-3''-deoxythymidine (zidovudine; ) or 2'',3''-dideoxyinosine (didanosine; ), in HeLa cells stably expressing CD4 (IC₅₀s = 5.8-21 μM). Abacavir inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes with a mean IC₅₀ value of 0.26 μM. It inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 cells (IC₅₀ = 7 μM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of feline immunodeficiency virus (FIV) in plaque reduction assays (IC₅₀s = 32 and 0.4 μM, respectively). Formulations containing abacavir have been used in the treatment of HIV infection.

Chemische Eigenschaften

White Solid

Verwenden

A labelled nucleoside reverse transcriptase inhibitor (NRTI)

Abacavir-d4 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Abacavir-d4 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+8613564774135	zijue.cai@tsbiochem.com	United States	19885	58
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32321	50
Clearsynth Labs Limited	+91-22-26355700	info@clearsynth.com	India	9679	58
Cato Research Chemicals Inc.	020-81960175	min.he@cato-chem.com	China	1955	55
Shenzhen SUNGENING Bio-Medical Co., Ltd.	0755-28967200 13631290199	wxf@sungening.com	China	9578	60
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 +86-13028896684;	sales@rrkchem.com	China	57423	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11974	58
Nanjing Shizhou Biology Technology Co.,Ltd	17301488900	judy.xia@synzest.com	China	12582	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19704	58

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• (1S,4R)-4-[2-Amino-6-[(cyclopropyl-d4)amino]-9H-purin-9-yl]-2-cycpentene-1-methanol
• Abacavir-d4
• Ziagen-d4
• (1S,4R)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene-1-Methanol
• (1S-cis)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene- 1-Methanol
• 1592U89-d4
• ABC-d4
• Abacavir-d₄
• Abacavir D4 HCl
• ((1S,4R)-4-(2-amino-6-((cyclopropyl-2,2,3,3-d4)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol
• 1260619-56-4
• C14H14N6OD4
• C14H14D4N6O
• Bases & Related Reagents
• Intermediates & Fine Chemicals
• Isotope Labeled Compounds
• Nucleotides
• Isotope Labelled Compounds
• Pharmaceuticals