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4-Amino-1-tert-butyl-3-(3-methylbenzyl)pyrazolo[3,4-d]pyrimidine

4-Amino-1-tert-butyl-3-(3-methylbenzyl)pyrazolo[3,4-d]pyrimidine Struktur
956025-83-5
CAS-Nr.
956025-83-5
Englisch Name:
4-Amino-1-tert-butyl-3-(3-methylbenzyl)pyrazolo[3,4-d]pyrimidine
Synonyma:
VGG;3-MB-PP1;PP1 Analog III, 3-MB-PP1 - CAS 956025-83-5 - Calbiochem;4-Amino-1-tert-butyl-(3-methylbenzyl)pyrazolo[3,4-D]pyrimidine;4-Amino-1-tert-butyl-3-(3-methylbenzyl)pyrazolo[3,4-d]pyrimidine;1-tert-butyl-3-(3-Methylbenzyl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine;1-tert-butyl-3-[(3-methylphenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-amine;1-(tert-Butyl)-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine , 3MB-PP1;1-(1,1-Dimethylethyl)-3-[(3-methylphenyl)methyl]-1H-Pyrazolo[3,4-d]pyrimidin-4- amine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1,1-dimethylethyl)-3-[(3-methylphenyl)methyl]-
CBNumber:
CB81564769
Summenformel:
C17H21N5
Molgewicht:
295.38
MOL-Datei:
956025-83-5.mol

4-Amino-1-tert-butyl-3-(3-methylbenzyl)pyrazolo[3,4-d]pyrimidine Eigenschaften

Schmelzpunkt:
136-1380C
Siedepunkt:
475.5±40.0 °C(Predicted)
Dichte
1.20±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
L?slichkeit
Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand
White solid
pka
4.52±0.30(Predicted)
Farbe
White
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

4-Amino-1-tert-butyl-3-(3-methylbenzyl)pyrazolo[3,4-d]pyrimidine Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White Solid

Verwenden

A highly potent and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase

Allgemeine Beschreibung

A cell-permeable C3-enlarged PP1 (Cat. No. 567809) analog that is shown to act as a potent, ATP-competitive, and highly ASKA- (analog-sensitive kinase alleles) selective inhibitor against polo-like kinase 1C67V L130G (75% and 94% inhibition in cell-free kinase assays at 0.1 and 1 μM, respectively), ZAP-70C405V M414A/ZAP-70M414A (complete prevention and elimination, respectively, of αTCR-stimulated [Ca2+] elevation in ASKA transfectants when applied before or after αTCR stimulation at 6 μM), and SykM442A S505A (56% inhibition of phagocytosis of Ab-opsonized SRBC by ASKA macrophages at 6 μM), while exhibiting little or no activity toward the wild-type or other off-target cellular enzymes. Functional analog-sensitive allele mutants are valuable tools in pharmacological validation of drug development and in elucidating enzyme signalings and functions both in cultures in vitro and in animals in vivo when specific inhibitors against naturally occurring target enzymes are unavailable and/or generations of knockout animals/cells lacking the target enzymes appear to be difficult, infeasible, or simply impossible.

4-Amino-1-tert-butyl-3-(3-methylbenzyl)pyrazolo[3,4-d]pyrimidine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

4-Amino-1-tert-butyl-3-(3-methylbenzyl)pyrazolo[3,4-d]pyrimidine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 53)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49374 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43340 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
 jkinfo@jkchemical.com China 96815 76
Chemsky（shanghai）International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32321 50
BOC Sciences 1-631-485-4226; 16314854226
 info@bocsci.com United States 14055 65
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611
China 9891 58
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51456 80
  • 1-(1,1-Dimethylethyl)-3-[(3-methylphenyl)methyl]-1H-Pyrazolo[3,4-d]pyrimidin-4- amine
  • 3-MB-PP1
  • 4-Amino-1-tert-butyl-3-(3-methylbenzyl)pyrazolo[3,4-d]pyrimidine
  • 1-tert-butyl-3-(3-Methylbenzyl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine
  • 4-Amino-1-tert-butyl-(3-methylbenzyl)pyrazolo[3,4-D]pyrimidine
  • 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1,1-dimethylethyl)-3-[(3-methylphenyl)methyl]-
  • PP1 Analog III, 3-MB-PP1 - CAS 956025-83-5 - Calbiochem
  • 1-tert-butyl-3-[(3-methylphenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-amine
  • DAPK,Inhibitor,Polo-like Kinase (PLK),Cdk8,Leu93-ZIPK,Plk1,Ssn3,3MBPP1,inhibit,CDK,3MB PP1,3MB-PP1,Death associated protein kinase,cell division arise,Cyclin dependent kinase,Candida albicans
  • VGG
  • 1-(tert-Butyl)-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine , 3MB-PP1
  • 956025-83-5
  • Heterocyclic Compounds
  • Bases & Related Reagent
  • Heterocycles
  • Nucleotides
  • Protein Kinase Inhibitors and Activators
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