Colesevelam Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Colesevelam hydrochloride was launched as Welchol (formerly known as Cholestagel) in the US for the reduction of elevated levels of serum LDL cholesterol and accordingly, the decrease of the risk of vascular disease in patients with primary hypercholesterolemia. This orally administered cationic hydrogel is a non-absorbable, water-insoluble polymer of an hexanaminium chloride with N-(2-propenyl) decanamine, 2-propen-1-amine hydrochloride and chloromethyloxirane. It acts as a powerful bile acid sequestering agent, this binding and blockage of bile acids having the end result of compelling the removal of LDL cholesterol from the blood stream into the liver. In animals fed with a cholesterol-rich diet for several weeks, colesevelam demonstrated a good maintenance of low serum cholesterol levels, this activity being significantly greater when compared with cholestyramine. In several placebo-controlled studies, this agent decreased total cholesterol levels by 6 to 10% and LDL cholesterol levels by 9 to 20%. Combination therapy with the co-administration of a HMG-CoA reductase inhibitor (or statin) and colesevelam produced an additional reduction of 8-16% in LDL-cholesterol levels above that obtained with the statin alone. Due to its unique water-absorbing hydrogel formulation, this polymer is not absorbed at all from the GI tract, and thus, it is said to have a lower rate of side-effects (as the constipating effect) than the previously marketed bile acid sequestrants. Colesevelam hydrochloride may be used as a monotherapy or as a dual therapy with statins.

Verwenden

Colesevelam Hydrochloride is used to reduce elevated low-density lipoprotein (LDL) cholesterol in patients with primary hyperlipidemia as well as to improve glycemic control in patients with type 2 diabetes.

Definition

ChEBI: The hydrochloride of colesevelam. It is used as an orally administered bile acid sequestrant to reduce the amount of cholesterol and certain fatty substances in the blood.

Allgemeine Beschreibung

Colesevelam (Welchol) is one of themore recent additions to the class of bile acid-sequesteringagents. Its structure is rather novel, and at first glance, it appearsto look like the previous examples of cholestyramineand colestipol. It does not possess the chloride ions, however,and, strictly speaking, is not an anion-exchange resin.This compound has good selectivity for both the trihydroxyand dihydroxy bile acids. The selectivity for these hydroxylatedderivatives lends some insight into the reduced side effectscolesevelam possesses, compared with cholestyramineand colestipol. Unlike the older agents, colesevelam doesnot have a high incidence of causing constipation. This resultsfrom the compound’s ability to “pick up” water as a resultof its affinity for hydroxyl system (i.e., hydrogen bondingwith either the bile acid or water). In turn, this yieldssofter, gel-like materials that are easier to excrete.

Colesevelam Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Colesevelam Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	+86-18600796368 +86-18600796368	sales@sjar-tech.com	China	375	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21639	55
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TopScience Biochemical	00852-68527855	info@itopbiochem.com	China Hong Kong	902	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29815	58
Xi'an MC Biotech, Co., Ltd.	029-89275612 +8618991951683	mcbio_sales@163.com	China	2251	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7724	58
Dorne Chemical Technology co. LTD	+86-86-13583358881 +8618560316533	Ethan@dornechem.com	China	3106	58

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