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(+)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexan-3-carbonitril

(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Struktur
38321-02-7
CAS-Nr.
38321-02-7
Bezeichnung:
(+)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexan-3-carbonitril
Englisch Name:
(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile
Synonyma:
d-Verapamil;Dexverapami;Dexverapamil;Dexverapamil Hydrochloride;[R,(+)]-2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(N-methyl-3,4-dimethoxyphenethylamino)valeronitrile;(R)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile;(aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile;(αR)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl](methyl)amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile;Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (R)-;Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, (αR)-
CBNumber:
CB7941337
Summenformel:
C27H38N2O4
Molgewicht:
454.61
MOL-Datei:
38321-02-7.mol

(+)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexan-3-carbonitril Eigenschaften

Schmelzpunkt:
129-131°C
Siedepunkt:
586.1±50.0 °C(Predicted)
Dichte
1.058±0.06 g/cm3(Predicted)
pka
8.97±0.50(Predicted)

Sicherheit

(+)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexan-3-carbonitril Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Off-White Solid

Verwenden

Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells

Definition

ChEBI: A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has R configuration. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby p tentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil exhibits lower calcium antagonistic activity and toxicity than racemic verapamil.

(+)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexan-3-carbonitril Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(+)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexan-3-carbonitril Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 13)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+8613564774135
 zijue.cai@tsbiochem.com United States 19885 58
LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2123 70
Clearsynth Labs Limited +91-22-26355700
info@clearsynth.com India 9679 58
Energy Chemical 021-58432009 400-005-6266
 marketing@energy-chemical.com China 44918 58
QUALITY CONTROL SOLUTIONS LTD. 0755-66853366; 13670046396
 ORDERS@QCSRM.COM China 24342 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822
 czbjpharma@126.com China 18478 58
TargetMol Chemicals Inc. 15002134094
 marketing@targetmol.cn China 19704 58

38321-02-7((+)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexan-3-carbonitril)Verwandte Suche:

  • Dexverapamil
  • (aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile
  • Dexverapami
  • Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (aR)- (9CI)
  • Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (R)-
  • d-Verapamil
  • (aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile Hydrochloride
  • Dexverapamil Hydrochloride
  • (R)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile
  • (αR)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl](methyl)amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile
  • [R,(+)]-2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(N-methyl-3,4-dimethoxyphenethylamino)valeronitrile
  • Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, (αR)-
  • 38321-02-7
  • C27H39ClN2O4
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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