AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36:Reizt die Augen.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Verwenden
Autocamtide 2-related inhibitory peptide has been used:
- To inhibit calmodulin kinase II (CaMKII) action in virulent Theileria infected macrophages
- To study its influence on oxidative stress associated with neural cell death after hypoxia-ischemia, using neonatal hippocampal slice cultures
- To quench the phosphorylation of recombinant synGA (GTPase-activating protein) induced by CaMKII
Biochem/physiol Actions
Calmodulin kinase II facilitates the calcium-dependent L-type calcium channels. Autocamtide 2-related inhibitory peptide action does not influence cAMP (cyclic adenosine monophosphate)-dependent protein kinase II, calmodulin-dependent protein kinase IV and protein kinase C. Increased expression of calmodulin kinase II is observed in structural heart disease, indicated by myocardial infarction. Thus, inhibition of calmodulin kinase II activity might serve as a protective effect against structural heart disease, as it is found to prevent cardiac hypertrophy, dilation and dysfunction.
AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
