TAXIFOLIN 3-O-RHAMNOSIDE
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- CAS-Nr.
- 29838-67-3
- Englisch Name:
- TAXIFOLIN 3-O-RHAMNOSIDE
- Synonyma:
- Astilbin;(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-3,4-dihydro-2H-chroMen-3-yl 6-deoxy-alpha-L-Mannopyranoside;Loastilin;Astilbin-RM;Taxifolin 3-rhaMnoside;Taxifolin 3-o-rhamnoside;Astilbin (6CI, 7CI, 8CI);Dihydroquercetin 3-rhamnoside;Astilbin Taxifolin 3-O-rhaMnoside;Astilbin froM Engelhardtia roxburghiana
- CBNumber:
- CB7507018
- Summenformel:
- C21H22O11
- Molgewicht:
- 450.4
- MOL-Datei:
- 29838-67-3.mol
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TAXIFOLIN 3-O-RHAMNOSIDE Eigenschaften
- Schmelzpunkt:
- 180 °C (decomp)
- Siedepunkt:
- 801.1±65.0 °C(Predicted)
- Dichte
- 1.74
- storage temp.
- Sealed in dry,2-8°C
- L?slichkeit
- H2O: soluble1mg/mL, clear, colorless
- pka
- 7.34±0.60(Predicted)
- Aggregatzustand
- A crystalline solid
- Farbe
- White to off-white
- InChIKey
- ZROGCCBNZBKLEL-MQGABXIONA-N
- SMILES
- O([C@]1([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)[C@H]1C(C2=C(C=C(O)C=C2O[C@@H]1C1C=CC(O)=C(O)C=1)O)=O |&1:1,4,6,8,10,12,22,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
N |
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| R-S?tze: |
50 |
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| S-S?tze: |
61 |
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| RIDADR |
UN 3077 9 / PGIII |
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| WGK Germany |
3 |
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| HS Code |
29389090 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H400 |
Sehr giftig für Wasserorganismen. |
Kurzfristig (akut) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
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TAXIFOLIN 3-O-RHAMNOSIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Astilbin is a flavonoid that has been found in
S. glabra and has diverse biological activities. It inhibits cisplatin-induced increases in apoptosis and accumulation of reactive oxygen species (ROS) in HEK293 cells when used at a concentration of 200 μM. Astilbin (50 mg/kg) increases renal glutathione (GSH) levels and superoxide dismutase (SOD) and catalase activity and reduces serum creatinine and blood urea nitrogen (BUN) levels, renal IL-1β, IL-6, and TNF-α levels, apoptosis in kidney tissue, and kidney injury in a mouse model of cisplatin-induced nephrotoxicity. It reduces loss of dopaminergic neurons in the substantia nigra and increases striatal GSH levels and SOD activity in a mouse model of MPTP-induced Parkinson''s disease when administered at a dose of 50 mg/kg per day. Astilbin also reduces descent time in a pole test and increases traction test score in a mouse model of Parkinson''s disease, indicating reduced motor deficits. It reduces cell viability of MDA-MB-231 and MCF-7 cells (IC
50s = 167.9 and 191.6 μM, respectively), as well as inhibits migration and increases apoptosis when used at concentrations of 50 and 200 μM. Astilbin (20 mg/kg every other day for 14 days) reduces tumor growth in an MCF-7 mouse xenograft model.
Definition
ChEBI: A flavanone glycoside that is (+)-taxifolin substituted by a alpha-L-rhamnosyl moiety at position 3 via a glycosidic linkage.
TAXIFOLIN 3-O-RHAMNOSIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
TAXIFOLIN 3-O-RHAMNOSIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 230)Lieferanten
29838-67-3()Verwandte Suche:
- Taxifolin 3-o-rhamnoside
- Astilbin Taxifolin 3-O-rhaMnoside
- Taxifolin 3-rhaMnoside
- Astilbin froM Engelhardtia roxburghiana
- Dihydroquercetin 3-rhamnoside
- (2R,3R)-3-[(6-Deoxy-alpha-L-mannopyranosyloxy)]-2-(3,4-dihydroxy-phenyl)-2,3-dihydro-5,7-dihydroxy-4H-chromen-4-one
- (2S,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy-chroman-4-one
- (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy-chroman-4-one
- Astilbin, 98%, from Smilax glabra Roxb.
- 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-, (2R,3R)-
- (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3-dihydrochromen-4-one
- (2R,3R)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)chroman-4-one
- (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-3,4-dihy...
- Astilbin
- (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-3,4-dihydro-2H-chroMen-3-yl 6-deoxy-alpha-L-Mannopyranoside
- Astilbin (6CI, 7CI, 8CI)
- Loastilin
- Astilbin-RM
- 29838-67-3
- Inhibitors
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
