FEROTKYRPUJIEB-UHFFFAOYSA-N Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0321 is a potent and selective G9a HMTase inhibitor, exhibiting a K_i value of 63 pM. UNC0321 inhibits G9a with assay-dependent IC₅₀ values of 6-9 nM and GLP, a closely-related H3K9 HMTase, with assay-dependent IC₅₀ values of 15-23 nM. It is more than 40,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and JMJD2E.

FEROTKYRPUJIEB-UHFFFAOYSA-N Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

FEROTKYRPUJIEB-UHFFFAOYSA-N Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19704	58

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• FEROTKYRPUJIEB-UHFFFAOYSA-N
• UNC0321 TFA
• 1934302-25-6