N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Compound 43 TAO kinase inhibitor is an ATP-competitive inhibitor of the thousand-and-one amino acid kinases TAOK1 and TAOK2 (IC₅₀s = 11 and 15 nM, respectively). It is selective for TAOK1 and TAOK2 over 62 kinases in a panel, but does inhibit TAOK3 by 87% and seven additional kinases by 21-52%. Compound 43 TAO kinase inhibitor inhibits proliferation of SK-BR-3, BT-549, and MCF-7 cells by 94, 82, and 46%, respectively, at a concentration of 10 μM. It reduces tau phosphorylation by TAOK2 at residues S262/S356 and S202/T205/S208 when used at concentrations ranging from 5 to 60 μM in a kinase assay and at residues S202/T205/S208 when used at concentrations of 5, 10, and 30 μM in HEK293 cells. Compound 43 TAO kinase inhibitor reduces tau phosphorylation of residues T123 and T427, which are phosphorylated by TAOK1 and TAOK2 in vitro and have been identified in tangles in Alzheimer’s disease brain tissue. It also reduces tau phosphorylation in cortical neurons in a transgenic mouse model of tauopathy and in induced pluripotent stem cell-derived neurons from patients with frontotemporal lobar degeneration.

Verwenden

CP 43 is a potent TAO kinase (TAOK) inhibitor (IC50 values are 11 nM/L and 15 nM/L for TAOK1 and TAOK2, respectively). Inhibits TAOK phosphorylation and activation of JNK in vitro. Also prolongs duration of mitosis and increases mitotic cell death in the SKBR3 breast cancer cell line.

N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32965	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30233	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Struchem Co., Ltd.	0512-0512-63009836 15365350169	helen@struchem.com	China	3984	60
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Shanghai SuperLan Chemcial Technique Centre	021-2022843681 15618226720	lucy@atkchemical.com	China	9987	58
Chongqing Chemieliva Pharmaceutical Co., Ltd.	023-67770219	jessica.hu@chemieliva.com	China	1469	60

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• N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide
• N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]-4-phenylbenzamide
• CP 43
• TAOK inhibitor 43
• N-[2-Oxo-2-(1,2,3,4-tetrahydro-1-naphthalenylamino)ethyl]-4-biphenylcarboxamide
• N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide
• [1,1'-Biphenyl]-4-carboxamide, N-[2-oxo-2-[(1,2,3,4-tetrahydro-1-naphthalenyl)amino]ethyl]-
• CP 43,TAO Kinase inhibitor-1,MAP kinase kinase kinase, MEKK, MAPKKK,CP43,CP-43,inhibit,TAO Kinase inhibitor 1,MAP3K,Inhibitor,TAO Kinase inhibitor1
• TAO Kinase inhibitor 1, 10 mM in DMSO
• 850467-66-2