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Tubulysin B

Tubulysin B Struktur
205304-87-6
CAS-Nr.
205304-87-6
Englisch Name:
Tubulysin B
Synonyma:
Tubulysin B;(2S,4R)-4-({2-[(1R,3R)-1-(acetyloxy)-3-[(2S,3S)-N-[(butanoyloxy)methyl]-3-methyl-2-{[(2R)-1-methylpiperidin-2-yl]formamido}pentanamido]-4-methylpentyl]-1,3-thiazol-4-yl}formamido)-5-(4-hydroxyphenyl)-2-methylpentanoic acid;Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-
CBNumber:
CB73339922
Summenformel:
C42H63N5O10S
Molgewicht:
830.05
MOL-Datei:
205304-87-6.mol

Tubulysin B Eigenschaften

Siedepunkt:
978.0±65.0 °C(Predicted)
Dichte
1.204±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
Soluble in DMSO
Aggregatzustand
Solid
pka
4.52±0.23(Predicted)
Farbe
White to off-white
InChIKey
HWCIETDQUHYHGQ-OSGLCLOFNA-N

Sicherheit

Tubulysin B Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agent isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug-resistant properties. It is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis.

Tubulysin B Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Tubulysin B Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 15)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Accendatech Co., Ltd.
+8613132578992
yunhao.liu@accendatech.com China 251 58
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32956 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
BOC Sciences
16314854226; +16314854226
inquiry@bocsci.com United States 19741 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696,15000506266 15000506266
China 4574 55
Angel Pharmatech, Ltd. 17317130613
3358272972@qq.com China 3254 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312
liming@bio-fount.com China 9729 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 0571-85361029
synstar518@163.com China 1990 58
Tianjin Shangde Medicine Edge Technology Co., Ltd 13370460931
sales@accendatech.com China 11 58
Hangzhou FuRun Pharmaceutical Technology Co., Ltd 15658004993
1900830611@qq.com China 965 58

  • Tubulysin B
  • Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-
  • (2S,4R)-4-({2-[(1R,3R)-1-(acetyloxy)-3-[(2S,3S)-N-[(butanoyloxy)methyl]-3-methyl-2-{[(2R)-1-methylpiperidin-2-yl]formamido}pentanamido]-4-methylpentyl]-1,3-thiazol-4-yl}formamido)-5-(4-hydroxyphenyl)-2-methylpentanoic acid
  • 205304-87-6
  • C42H63N5O10S
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