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BAY-1125976.

BAY-1125976. Struktur
1402608-02-9
CAS-Nr.
1402608-02-9
Englisch Name:
BAY-1125976.
Synonyma:
CS-2913;BAY1125976;BAY 1125976;BAY-1125976.;BAY-1125976; BAY 1125976;BAY1125976, 10 mM in DMSO;inhibit,Inhibitor,Protein kinase B,Akt,BAY 1125976,BAY1125976,PKB,BAY-1125976;2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide;Imidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-
CBNumber:
CB73133467
Summenformel:
C23H21N5O
Molgewicht:
383.45
MOL-Datei:
1402608-02-9.mol

BAY-1125976. Eigenschaften

storage temp. 
Store at -20°C
L?slichkeit
DMSO:13.0(Max Conc. mg/mL);33.9(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);13.04(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.65(Max Conc. mM)
Aggregatzustand
A crystalline solid
Farbe
Light yellow to yellow

Sicherheit

BAY-1125976. Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

BAY-1125976 is an allosteric inhibitor of Akt1 and -2 (IC50s = 5.2 and 18 nM, respectively, in a time-resolved FRET assay). It is selective for Akt1 and -2 over Akt3 (IC50 = 427 nM in the same assay) but does inhibit the activity of the receptor tyrosine kinases FLT1, -3, -4, and Mer by greater than 50% in a panel of 227 kinases at 1 μM. BAY-1125976 inhibits the proliferation of 23 cancer cell lines (IC50s = 0.02-10 μM) and reduces tumor growth in KPL-4, MCF-7, and patient-derived xenograft (PDX) mouse models when administered at a dose of 50 mg/kg per day.

BAY-1125976. Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

BAY-1125976. Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 66)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32965 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581
 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139
 orders@jknbiochem.com China 5221 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
Nantong Hi-Future Biotechnology Co., Ltd 18051384581
 sales@chemhifuture.com China 3021 58
  • BAY 1125976
  • BAY1125976
  • BAY-1125976.
  • 2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide
  • BAY-1125976; BAY 1125976
  • CS-2913
  • Imidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-
  • inhibit,Inhibitor,Protein kinase B,Akt,BAY 1125976,BAY1125976,PKB,BAY-1125976
  • BAY1125976, 10 mM in DMSO
  • 1402608-02-9
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