Anti-TCTEX1L Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project
(www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these
protocols and other useful information about Prestige Antibodies and the HPA, visit .
Allgemeine Beschreibung
Monoclonal Anti-DYNLT3 (mouse IgG2a isotype) is derived from the hybridoma R1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with rat dynein 3 light chain-myosin basic protein fusion protein. DYNLT3 belongs to the Tctex-light chain family. It is also known as rp3.
Biochem/physiol Actions
Cytoplasmic dynein motor complex is responsible for minus-end, microtubule-based motile processes. It is thus involved in a wide range of eukaryotic cellular processes including trafficking of membranal vesicles, viruses and other intracellular particles. DYNLT3 is a light chain subunit of the complex that binds to Bub3, a spindle checkpoint protein and is depleted from the kinetochore during chromosome alignment. It contributes to dynein cargo binding specificity as dynein binds directly to a component of the spindle checkpoint complex through this light chain. The interaction of the Herpes simplex virus capsid protein VP26 with dynein light chains facilitates the binding of the virus capsid to cytoplasmic dynein during cellular infection.
Anti-TCTEX1L Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
