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N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide

N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Struktur
945128-26-7
CAS-Nr.
945128-26-7
Englisch Name:
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
Synonyma:
ML249;CYM5541;CYM-5541;CID-17253208;CYM 5541(ML-249);CYM-5541;CYM 5541;ML-249;ML 249;ML249;N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide;N,N-Dicyclohexyl-5-cyclopropylisoxazole-3-carboxamide;3-Isoxazolecarboxamide, N,N-dicyclohexyl-5-cyclopropyl-;N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
CBNumber:
CB72750683
Summenformel:
C19H28N2O2
Molgewicht:
316.44
MOL-Datei:
945128-26-7.mol

N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Eigenschaften

Siedepunkt:
503.1±38.0 °C(Predicted)
Dichte
1.14±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: soluble5mg/mL, clear (warmed)
pka
-2.57±0.20(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The sphingosine 1-phosphate (S1P) receptor S1P3 has roles in vasodilation, epithelial barrier function, cardioprotection, fibrosis, immunity, and inflammation. CYM 5541 is a selective, allosteric agonist of S1P3 (EC50 = 72-132 nM). It less effectively activates S1P1 (EC50 = 28-38 μM) and is ineffective at S1P2, S1P4, and S1P5 as well as a panel of other receptors, ion channels and transporters.

Verwenden

CYM 5541, is a selective allosteric agonist of SAR and S1P3 receptors.

Biochem/physiol Actions

CYM-5541 is an allosteric agonist selective for the Sphingosine 1-phosphate (S1P) S1P3 receptor subtype. CYM-5541 occupies a different chemical space in the ligand binding pocket of S1P3 than S1P does, a lower hydrophobic region around transmembrane helix TM6. CYM-5541 shows great selectivity and stability with an EC50 of between 72 and 132 nM compared to S1P1 EC50 > 10 μM, S1P2 EC50 > 50 μM, S1P4 EC50 > 50 μM, and S1P5 EC50 > 25 μM and no significant activities for a panel of 55 GPCRs, ion channels, and transporters.

N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 75)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30238 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
BOC Sciences 1-631-485-4226; 16314854226
 info@bocsci.com United States 14055 65
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66099280 17798518460
 cfzhang@aikonchem.com China 19915 55
  • CYM5541
  • CYM-5541
  • ML249
  • N,N-Dicyclohexyl(5-cyclopropylisoxazol-3-yl)-carboxamide
  • N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
  • CYM 5541(ML-249)
  • CYM-5541;CYM 5541;ML-249;ML 249;ML249
  • N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
  • CID-17253208
  • 3-Isoxazolecarboxamide, N,N-dicyclohexyl-5-cyclopropyl-
  • CYM5541,inhibit,ML-249,LPL Receptor,CYM-5541,ML 249,Inhibitor,Lysophospholipid Receptor
  • N,N-Dicyclohexyl-5-cyclopropylisoxazole-3-carboxamide
  • 945128-26-7
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