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Phthalazinone pyrazole

Phthalazinone pyrazole Struktur
880487-62-7
CAS-Nr.
880487-62-7
Englisch Name:
Phthalazinone pyrazole
Synonyma:
Phthalazinone pyrazole;Phthalazinone pyrazole Exclusive;4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one;4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one;1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-;4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-1,2-dihydrophthalazin-1-one;Phthalazinone pyrazole,inhibit,human embryonic stem cells,Aurora Kinase,hepatocyte-like cell,Inhibitor,HLCs,Aurora-A kinase,EMT,apoptosis,tumor growth,oral,epithelial-mesenchymal transition
CBNumber:
CB72592005
Summenformel:
C18H15N5O
Molgewicht:
317.34
MOL-Datei:
880487-62-7.mol

Phthalazinone pyrazole Eigenschaften

Siedepunkt:
557.7±52.0 °C(Predicted)
Dichte
1.35±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
insoluble in EtOH; insoluble in H2O; ≥7.14 mg/mL in DMSO
Aggregatzustand
crystalline solid
pka
13.83±0.10(Predicted)
Farbe
Brown to gray

Sicherheit

Phthalazinone pyrazole Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Aurora A, involved in centrosomal assembly and acentrosomal spindle assembly, is overexpressed in many tumors. Phthalazinone pyrazole is a potent inhibitor of Aurora A kinase (IC50 = 31 nM). It does not inhibit Aurora B kinase at doses up to 100 μM. Phthalazinone pyrazole inhibits the proliferation of HCT116, COLO 205, and MCF-7 cells (IC50 = 7.8, 2.9, and 1.6 μM, respectively).

Phthalazinone pyrazole Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Phthalazinone pyrazole Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 34)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581
 sales@chemhifuture.com China 3135 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4575 55
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994
 2853530910@QQ.com China 8011 62
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686
 sales@rechemscience.com China 2986 58
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136
 Sales@ATKchemical.com China 7295 58
Shanghai Yu Ben Biotechnology Co., Ltd. 15502154572
 yuben012@sina.com China 505 58
DC Chemicals 021-58447131 13564518121
 sales@dcchemicals.com China 9409 58
  • Phthalazinone pyrazole
  • Phthalazinone pyrazole Exclusive
  • 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one
  • 1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-
  • 4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one
  • Phthalazinone pyrazole,inhibit,human embryonic stem cells,Aurora Kinase,hepatocyte-like cell,Inhibitor,HLCs,Aurora-A kinase,EMT,apoptosis,tumor growth,oral,epithelial-mesenchymal transition
  • 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-1,2-dihydrophthalazin-1-one
  • 880487-62-7
  • 88048-62-7
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