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Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-

Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- Struktur
168682-53-9
CAS-Nr.
168682-53-9
Englisch Name:
Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-
Synonyma:
CS-1110;Ezatiostat;Terrapin 199;Ezatiostat, >96%;Ezatiostat, >=98%;TER199(free base);Ezatiostat (TER199);Ezatiostat salt free;Ezatiostat 168682-53-9;Ezatiostat TFA (free base)
CBNumber:
CB72563432
Summenformel:
C27H35N3O6S
Molgewicht:
529.65
MOL-Datei:
168682-53-9.mol

Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- Eigenschaften

Schmelzpunkt:
>94°C (dec.)
Siedepunkt:
749.7±60.0 °C(Predicted)
Dichte
1.216±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
pka
12?+-.0.46(Predicted)
Aggregatzustand
Solid
Farbe
White to Off-White

Sicherheit

Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Ezatiostat is an inhibitor of glutathione S-transferase pi 1-1 (GSTP1-1; Ki = 0.4 μM). It is selective for GSTP1-1 over GSTα and GSTμ family GSTs (Kis = 20-75 μM). Ezatiostat also inhibits the protein-protein interaction between GSTP1-1 and JNK1. In vivo, ezatiostat (75 mg/kg) increases the number of circulating white blood cells in Gstp1 wild-type, but not Gstp1-/-, mice.

Verwenden

Ezatiostat is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1, the most prevalent Glutathione S-transferases (GST) isozyme in nonhepatic tissues, catalytic activity with minimal effect on the related GSTα and -μ families.

Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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168682-53-9()Verwandte Suche:

  • (S)-ETHYL 2-AMINO-5-((R)-3-(BENZYLTHIO)-1-((R)-2-ETHOXY-2-OXO-1-PHENYLETHYLAMINO)-1-OXOPROPAN-2-YLAMINO)-5-OXOPENTANOATE
  • (2R)-L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycine 1,3-diethyl ester
  • Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-
  • Ezatiostat
  • Terrapin 199
  • Ezatiostat, >=98%
  • Ezatiostat, >96%
  • CS-1110
  • TER 199; TLK-199; TELINTRA
  • Ezatiostat (TER199)
  • Ezatiostat TFA (free base)
  • TER199(free base)
  • Glycine, L-γ-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-, 1,3-diethyl ester, (2R)-
  • Ethyl N5-((R)-3-(benzylthio)-1-(((R)-2-ethoxy-2-oxo-1-phenylethyl)amino)-1-oxopropan-2-yl)-L-glutaminate
  • Ezatiostat salt free
  • Ezatiostat 168682-53-9
  • 168682-53-9
  • C27H35N3O6S
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