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N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide

N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide Struktur
1199236-64-0
CAS-Nr.
1199236-64-0
Englisch Name:
N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide
Synonyma:
Z-944;Ulixacaltamide;Ulixacaltamide (Z944);N-[[1-[2-(tert-butylamino)-2-;Ca channels,Inhibitor,Calcium Channel,Ca2+ channels,Z944,inhibit;N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide;4-[[(3-Chloro-5-fluorobenzoyl)aMino]Methyl]-N-(1,1-diMethylethyl)-1-piperidineacetaMide;1-Piperidineacetamide, 4-[[(3-chloro-5-fluorobenzoyl)amino]methyl]-N-(1,1-dimethylethyl)-
CBNumber:
CB72543885
Summenformel:
C19H27ClFN3O2
Molgewicht:
383.89
MOL-Datei:
1199236-64-0.mol

N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide Eigenschaften

Schmelzpunkt:
122-124°C
Siedepunkt:
528.1±50.0 °C(Predicted)
Dichte
1.166±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
L?slichkeit
Chloroform (Slightly), Methanol (Slightly)
pka
13.65±0.46(Predicted)
Aggregatzustand
Solid
Farbe
White to Off-White

Sicherheit

N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Z944 is an inhibitor of T-type calcium channels (IC50s = 0.050-0.160 μM for the human recombinant voltage-gated calcium (Cav) channels Cav3.1, Cav3.2, and Cav3.3). It is selective for T-type channels over the N-type Cav2.2 channel (IC50 = 11 μM), as well as the rat L-type Cav1.2, human-ether-a-go-go (hERG/Kv11.1) potassium, and human voltage-gated sodium (Nav) channel Nav1.5 (IC50s = 32, 7.8, and 100 μM, respectively). Z944 (30 mg/kg) reduces the seizure duration and the amount of time rats spend in seizures in a model of absence epilepsy. It delays seizure progression in amygdala-kindled rats but does not inhibit seizures in fully kindled rats.

Chemische Eigenschaften

White Solid

Verwenden

As N-Piperidinyl acetamide derivatives, N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide can be used as calcium channel blockers and their use in the treatment of obesity.

N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 41)Lieferanten
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Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4575 55
  • 4-[[(3-Chloro-5-fluorobenzoyl)aMino]Methyl]-N-(1,1-diMethylethyl)-1-piperidineacetaMide
  • N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide
  • Z-944
  • 1-Piperidineacetamide, 4-[[(3-chloro-5-fluorobenzoyl)amino]methyl]-N-(1,1-dimethylethyl)-
  • N-[[1-[2-(tert-butylamino)-2-
  • Ca channels,Inhibitor,Calcium Channel,Ca2+ channels,Z944,inhibit
  • Ulixacaltamide (Z944)
  • Ulixacaltamide
  • 1199236-64-0
  • C19H27ClFN3O2
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
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