2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
CAS-Nr.
500579-04-4
Englisch Name:
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
Synonyma:
GNT61;CS-867;GANT 61;NSC 136476;GANT61, >=98%;GANT-61,NSC 136476;GANT 61, 10 mM in DMSO;GANT61;GANT 61;NSC 136476;Hh/Gli Antagonist, GANT61;GANT 61, GLI1 and 2 inhibitor
CBNumber:
CB72518922
Summenformel:
C27H35N5
Molgewicht:
429.6
MOL-Datei:
500579-04-4.mol
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Eigenschaften
Schmelzpunkt:
110 - 113°C
Siedepunkt:
549.0±50.0 °C(Predicted)
Dichte
1.134±0.06 g/cm3(Predicted)
storage temp.
2-8°C
L?slichkeit
DMSO: >2mg/mL
pka
5.97±0.10(Predicted)
Aggregatzustand
powder
Farbe
white to off-white
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.
Biochem/physiol Actions
GANT61 blocks hedgehog pathway signaling by inhibiting the transcripional activity of Gli1 (IC50 = 5 μM). GANT 61 led to a regression of 22Rv1 human prostate tumor cell xenografts in nude mice.
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 150)Lieferanten
China 124
India 2
United Kingdom 2
United States 22
Global 150
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
GANT 61
Benzenamine, 2,2'-[[dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl-
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine] GANT61
GNT61
NSC 136476
GANT61, >=98%
GANT-61,NSC 136476
2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylanilin
InSolution? Hh/Gli Antagonist, GANT61
2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline
InSolution Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem
CS-867
GANT61; GANT-61; NSC 136476;GANT 61
GANT61;GANT 61;NSC 136476
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine USP/EP/BP
2,2'-((2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline)
2,2’-[[2-(4-Pyridyl)dihydropyrimidine-1,3(2H,4H)-diyl]bis(methylene)]bis(N,N-dimethylaniline)
GANT 61, GLI1 and 2 inhibitor
GANT 61, 10 mM in DMSO
Hh/Gli Antagonist, GANT61
500579-04-4
C27H35N5
Inhibitors