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3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Struktur
412960-54-4
CAS-Nr.
412960-54-4
Englisch Name:
3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
Synonyma:
Eeyarestatin 1;Eeyarestatin I;Eeyarestatin I - CAS 412960-54-4 - Calbiochem;Eeyarestatin I - ES1 | ERAD inhibitor 1 | p97 inhibitor 1;3-(4-Chlorophenyl)-1-(3-(4-chlorophenyl)-5,5-dimethyl-1-(2-(2-(3-(5-nitrofuran-2-yl)allylidene)hydrazineyl)-2-oxoethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea;3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide;1-Imidazolidineacetic acid, 3-(4-chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-, 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
CBNumber:
CB72518902
Summenformel:
C27H25Cl2N7O7
Molgewicht:
630
MOL-Datei:
412960-54-4.mol

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Eigenschaften

Dichte
1.49±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: soluble5mg/mL
Aggregatzustand
Light yellow-orange solid
pka
9.13±0.40(Predicted)
Farbe
Yellow to orange

Sicherheit

WGK Germany  3

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation.

Biochem/physiol Actions

Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the proapoptotic protein NOXA.

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • 3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
  • Eeyarestatin I
  • Eeyarestatin 1
  • Eeyarestatin I - ES1 | ERAD inhibitor 1 | p97 inhibitor 1
  • Eeyarestatin I - CAS 412960-54-4 - Calbiochem
  • 1-Imidazolidineacetic acid, 3-(4-chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-, 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
  • 3-(4-Chlorophenyl)-1-(3-(4-chlorophenyl)-5,5-dimethyl-1-(2-(2-(3-(5-nitrofuran-2-yl)allylidene)hydrazineyl)-2-oxoethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea
  • 412960-54-4
  • C27H25Cl2N7O7
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