5-Bromo-7-methyl-1H-indole
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- CAS-Nr.
- 15936-81-9
- Englisch Name:
- 5-Bromo-7-methyl-1H-indole
- Synonyma:
- EOS-61850;5-BroMo-7-Methylindole;7-methyl-5-bromo-1H-indole;5-Bromo-7-methyl-1H-indole;1H-Indole, 5-bromo-7-methyl-
- CBNumber:
- CB72516322
- Summenformel:
- C9H8BrN
- Molgewicht:
- 210.07
- MOL-Datei:
- 15936-81-9.mol
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5-Bromo-7-methyl-1H-indole Eigenschaften
- Siedepunkt:
- 165 °C(Press: 0.1 Torr)
- Dichte
- 1.503 g/mL at 25 °C
- Brechungsindex
- n20/D1.648
- Flammpunkt:
- >110℃
- storage temp.
- Sealed in dry,Room Temperature
- Aggregatzustand
- Solid or semi-solid or lump or liquid
- pka
- 16.34±0.30(Predicted)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H318 |
Verursacht schwere Augensch?den. |
Schwere Augensch?digung |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS05.jpg" width="20" height="20" /> |
P280, P305+P351+P338, P310 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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5-Bromo-7-methyl-1H-indole Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthese
5-Bromo-7-methyl-1H-indole is synthesised from 4-bromo-6-(trimethylsilylacetylenyl)-2-methylaniline by reacting with potassium tert-butyrate and sodium hydride in the presence of inert gas. The steps are as follows:
Add sodium hydride (2.64g, 0.11mol) and DMF (70mL) to a 250ml three-necked flask at room temperature and under nitrogen protection.Stir and dissolve; a solution of the compound of formula IV (14g, 0.05mol) dissolved in DMF (30mL) is slowly added dropwise to the potassium tert-butoxide solution. After the addition, the reaction system was heated to 60 degrees and kept for 2 hours. After the reaction was completed, the reaction solution was poured into ice water, extracted with methyl tert-butyl ether, and washed with sodium bicarbonate aqueous solution and brine in turn.It was then dried over anhydrous sodium sulfate, filtered, and concentrated. The crude product is purified by silica gel column chromatography to obtain the compound of 5-bromo-7-methylindole. Yield: 8.36 g, yield: 80%.
5-Bromo-7-methyl-1H-indole Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Bromo-7-methyl-1H-indole Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 75)Lieferanten
- 5-Bromo-7-methyl-1H-indole
- 5-BroMo-7-Methylindole
- 1H-Indole, 5-bromo-7-methyl-
- EOS-61850
- 7-methyl-5-bromo-1H-indole
- 15936-81-9
