SC 57461A
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- CAS-Nr.
- 423169-68-0
- Englisch Name:
- SC 57461A
- Synonyma:
- SC 57461;SC 57461A;SC-57461 Hydrochloride;N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-β-alaninehydrochloride;3-((3-(4-Benzylphenoxy)propyl)(methyl)amino)propanoic acid hydrochloride;inhibit,SC57461A,SC 57461A,Leukotriene A4,SC-57461A,Inhibitor,Aminopeptidase,orally active,LTA4 hydrolase
- CBNumber:
- CB72446539
- Summenformel:
- C20H25NO3.ClH
- Molgewicht:
- 363.882
- MOL-Datei:
- 423169-68-0.mol
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SC 57461A Eigenschaften
- Schmelzpunkt:
- 163-165°C
- storage temp.
- Desiccate at +4°C
- L?slichkeit
- DMSO: >5mg/mL
- Aggregatzustand
- powder
- Farbe
- white to off-white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22-36/37/38 |
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| S-S?tze: |
26 |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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SC 57461A Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Leukotriene A
4 (LTA
4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB
4 from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. SC-57461A is a potent, orally active inhibitor of LTA
4 hydrolase that blocks ionophore-stimulated LTB
4 synthesis in whole blood (IC
50 = 49 nM). It blocks both the hydrolase and aminopeptidase activity
in vitro. SC-57461A is without effect against other enzymes of the arachidonic acid cascade, including 5-lipoxygenase, LTC
4 synthase, COX-1, and COX-2. In a rat model of ionophore-induced peritoneal eicosanoid production, SC-57461A inhibits LTB
4 biosynthesis without affecting LTC
4 or 6-keto prostaglandin F
1α production . Oral or topical pretreatment with SC-57461A before challenge with arachidonic acid blocks ear edema in mice.
Chemische Eigenschaften
White Solid
Verwenden
SC 57461A is a potent and selective inhibitor of LTA4.
Biologische Aktivit?t
Potent and selective inhibitor of LTA 4 hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC 4 synthase and 5-lipoxygenase. Potently inhibits LTB 4 production in whole blood (IC 50 = 49 nM). Orally active.
SC 57461A Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SC 57461A Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 78)Lieferanten
- SC-57461 Hydrochloride
- SC 57461A
- N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-β-alaninehydrochloride
- SC 57461
- inhibit,SC57461A,SC 57461A,Leukotriene A4,SC-57461A,Inhibitor,Aminopeptidase,orally active,LTA4 hydrolase
- 3-((3-(4-Benzylphenoxy)propyl)(methyl)amino)propanoic acid hydrochloride
- 423169-68-0
- Amines
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pfizer compounds
- Pharmaceuticals
