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derquantel

derquantel Struktur
187865-22-1
CAS-Nr.
187865-22-1
Englisch Name:
derquantel
Synonyma:
derquantel;Unii-0L0ugk6oox;2-Deoxoparaherquamide;Derquantel in methanol;2-DeoxoparaherquaMide, 2-DeoxoparaherquaMide A, 2-DesoxoparaherquaMide A, PF 00520904, PNU 141962;Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,7'(8'H)-[5H,6H-5a,9a](iminomethano)[1H]cyclopent[f]indolizin]-10'-one, 2',3',8'a,9,9',10-hexahydro-1'-hydroxy-1',4,4,8',8',11'-hexamethyl-, (1'R,5'aS,7'R,8'aS,9'aR)-
CBNumber:
CB71518503
Summenformel:
C28H37N3O4
Molgewicht:
479.61
MOL-Datei:
187865-22-1.mol

derquantel Eigenschaften

Siedepunkt:
641.3±55.0 °C(Predicted)
Dichte
1.34
storage temp. 
Store at -20°C
L?slichkeit
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
Aggregatzustand
A solid
pka
15.18±0.60(Predicted)
Farbe
White to off-white
JECFA Number
75

Sicherheit

derquantel Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Derquantel is an anthelmintic spiroindole that acts as a nicotinic acetylcholine receptor antagonist, causing flaccid paralysis and expulsion of nematodes. A combination of derquantel and the macrocyclic lactone, abamectin , has been found to have synergistic anthelmintic effects against gastrointestinal nematode parasites in sheep.

Verwenden

Derquantel is a semi-synthetic paraherquamide analogue prepared by removal of the 2-oxo group in a four-step sequence of N-protection, reduction, N-deprotection and a final reduction. Derquantel isa potent nematocide and was the first paraherquamide to be successfully commercialised in combination with avermectin. Derquantel, like other paraherquamides, induces a flaccid paralysis in nematodes thought to be due to inhibition of nicotinic acetylcholine receptors acting as an antagonist of acetylcholine.

derquantel Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

derquantel Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 41)Lieferanten
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Meng Cheng Technology (Shanghai) Co., LTD 400-820-6829
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  • derquantel
  • 2-Deoxoparaherquamide
  • Unii-0L0ugk6oox
  • 2-DeoxoparaherquaMide, 2-DeoxoparaherquaMide A, 2-DesoxoparaherquaMide A, PF 00520904, PNU 141962
  • Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,7'(8'H)-[5H,6H-5a,9a](iminomethano)[1H]cyclopent[f]indolizin]-10'-one, 2',3',8'a,9,9',10-hexahydro-1'-hydroxy-1',4,4,8',8',11'-hexamethyl-, (1'R,5'aS,7'R,8'aS,9'aR)-
  • Derquantel in methanol
  • 187865-22-1
  • C28H37N3O4
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