7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
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- CAS-Nr.
- 73942-87-7
- Englisch Name:
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- Synonyma:
- 8-Dimethoxy-1;Ivabradine Impurity 13;Ivabradine Impurity 73;Ivabradine Impurity 22;3-dihydro-2H-3-benzazepin-2-one;7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one;7,8-dimethoxy-1,3-dihydro-1-benzazepin-2-one;7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one;7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one>1,3-Dihydro-7,8-dimethoxybenzo[d]azepin-2-one
- CBNumber:
- CB71503994
- Summenformel:
- C12H13NO3
- Molgewicht:
- 219.24
- MOL-Datei:
- 73942-87-7.mol
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7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Eigenschaften
- Schmelzpunkt:
- 244.0 to 248.0 °C
- Siedepunkt:
- 455.8±45.0 °C(Predicted)
- Dichte
- 1.167
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- Chloroform (Slightly), DMSO (Slightly)
- Aggregatzustand
- Solid
- pka
- 13.29±0.20(Predicted)
- Farbe
- Off-White to Pale Beige
- LogP
- 1.23 at 23℃ and pH6.47
- Oberfl?chenspannung
- 71mN/m at 36.9mg/L and 19℃
- CAS Datenbank
- 73942-87-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H412 |
Sch?dlich für Wasserorganismen, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 3 |
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P273, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is a substituted benzazepinonee derivative used in the preparation of bradycardic agents as well as isoform-selective f-current blockers.
Application
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is used in the industrial preparation of pharmaceuticals and can be reacted with trifluoroacetic acid to form 3,4-dimethoxyphenylacetic acid.
Synthese
1.Charge 142.0 g of N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl) acetamide, 710 ml of glacial acetic acid and 710 ml of conc. hydrochloric acid in a 3.0 L round bottom flask equipped with mechanical stirrer and thermometer pocket at 25°C.
2.Stir the mixture for 17 hours at 25°C.
3.Monitor the reaction by HPLC (starting material should be less than 4.0%).
4.Pour the reaction mixture on 3.0 kg of crushed ice, if HPLC complies.
5.Stir the mixture for 30 minutes and filter the solid material.
6.Wash the mixture with 1 L of water, suck dry and unload the material.
7.Dry the 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one under vacuum at 55-60°C till the LOD comes to below 0.5%.
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 310)Lieferanten
73942-87-7()Verwandte Suche:
- Ivabradine Impurity 13
- 1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one
- 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- 2H-3-Benzazepin-2-one,1,3-dihydro-7,8-diMethoxy-
- 1,3-Dihydro-7,8-dimethoxybenzo[d]azepin-2-one
- 7,8-diMethoxy-2,3-dihydro-1H-3-benzazepin-2-one
- 7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one
- 7,8-dimethoxy-1, 3-dihydro-2H-benzo[d] azepin-2-one
- 7,8-diMethoxy -1,3-dihydro-2H-3-Benzazepin-2-one/2H-3-Benzazepin-2-one, 1,3-dihydro-7,8-diMethoxy(For Ivabradine)
- 7,8-dimethoxy -1,3-dihydro-2H-3-Benzazepin-2-one/2H-3-Benzazepin-
2-one, 1,3-dihydro-7,8-dimethoxy
- 1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one 7,8-dimethoxy-1, 3-dihydro-2H-benzo[d] azepin-2-one
- 7,8-dimethoxy-1,3-dihydro-1-benzazepin-2-one
- 3-(3-((((R)-3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-1-hydroxy-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one
- Ivabradine Impurity 73
- 3-dihydro-2H-3-benzazepin-2-one
- 8-Dimethoxy-1
- 7,8 - Dimethoxy-1,3-Dichloro-2H-3-Benzazepin-2-one
- Ivabradine Impurity 22
- 7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one
- 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one>
- 7,8-dimethoxy-1,3-dihydro-2h-3-benzoazepine-2-one
- 7, 8-dimethoxy-1, 3-dihydro-2H-3-benzoze heptin-2-1, 7-dimethoxy-1, 3-dihydro-2H-3-benzoze heptin-2-1
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one CAS 73942-87-7
- Hot Sell 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- New Product 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzoazo-2-one
- 73942-87-7
- 73492-87-7
- Aromatics
- Heterocycles
- Intermediates
