SB 223412
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- CAS-Nr.
- 174636-32-9
- Englisch Name:
- SB 223412
- Synonyma:
- CS-1123;SB 223412;Talnetant (SB 223412);SB-223412; SB223412; SB 223412;3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;(S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide;(S)-3-Hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide;3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide;(-)-3-Hydroxy-2-phenyl-N-[1(S)-phenylpropyl]quinoline-4-carboxamide
- CBNumber:
- CB71333041
- Summenformel:
- C25H22N2O2
- Molgewicht:
- 382.45
- MOL-Datei:
- 174636-32-9.mol
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SB 223412 Eigenschaften
- Schmelzpunkt:
- 125.1-126.2℃
- Siedepunkt:
- 580.4±50.0 °C(Predicted)
- Dichte
- 1.212±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- L?slichkeit
- DMSO: soluble25mg/mL, clear
- Aggregatzustand
- powder
- pka
- 6.70±0.50(Predicted)
- Farbe
- white to beige
- Optische Aktivit?t
- [α]/D -25 to -31°, c = 0.5 in methanol
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher |
T |
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R-S?tze: |
25 |
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S-S?tze: |
45 |
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RIDADR |
UN 2811 6.1 / PGIII |
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Bildanzeige (GHS) |
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Alarmwort |
Achtung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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Sicherheit |
P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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SB 223412 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Talnetant is an antagonist of the neurokinin-3 (NK
3) receptor (K
i = 1 nM). It is selective for NK
3 over NK
1 and NK
2 receptors (K
is = 144 and >100,000 nM, respectively, in CHO cells expressing recombinant human receptors). Talnetant inhibits calcium mobilization induced by neurokinin B in HEK293 cells expressing human NK
3 receptors (IC
50 = 16.6 nM). It inhibits contractions induced by the NK
3 receptor agonist senktide in isolated rabbit iris sphincter muscle (pD
2 = 9.1). Talnetant (5-20 mg/kg) reduces senktide-induced head shakes and tail whips in mice. It also inhibits senktide-induced wet-dog shakes, increases extracellular dopamine and norepinephrine in the medial prefrontal cortex, and attenuates haloperidol-induced increases in nucleus accumbens dopamine levels in guinea pigs.
SB 223412 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SB 223412 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 77)Lieferanten
- SB 223412
- 3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
- (-)-(S)-N-(alpha-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxaMide
- TALNETANT//SB223412//3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxaMide
- (-)-3-Hydroxy-2-phenyl-N-[1(S)-phenylpropyl]quinoline-4-carboxamide
- (S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide
- 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide
- 3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide
- SB-223412; SB223412; SB 223412
- Talnetant (SB 223412)
- CS-1123
- Talnetant/(S)-3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
- 4-Quinolinecarboxamide, 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-
- (S)-3-Hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
- schizophrenia,SB223412,NK receptor,Inhibitor,hNK-2,Talnetant,Neurokinin Receptor,Tachykinin receptor,NK3 receptor,SB-223412,inhibit
- 174636-32-9