Pseudouridine
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- CAS-Nr.
- 1445-07-4
- Englisch Name:
- Pseudouridine
- Synonyma:
- PSEUDOURIDINE;Pseudo-UTP;5-Ribosyluracil;β-Pseudouridine;5-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione;y-Uridine;NSC 162405;Pseudoruidine;Pseudourindine;Pseudouricdine
- CBNumber:
- CB7125832
- Summenformel:
- C9H12N2O6
- Molgewicht:
- 244.2
- MOL-Datei:
- 1445-07-4.mol
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Pseudouridine Eigenschaften
- Schmelzpunkt:
- 222 °C
- Dichte
- 1.641±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- L?slichkeit
- Methanol (Very Slightly, Heated), Water (Slightly, Sonicated, Heated)
- pka
- 8.52±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- PH
- ～9.0
- maximale Wellenl?nge (λmax)
- 264nm(MeOH)(lit.)
- InChI
- InChI=1/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/s3
- InChIKey
- PTJWIQPHWPFNBW-IZFRNLNUNA-N
- SMILES
- O[C@@H]1[C@@H]([C@@H](CO)O[C@H]1C1=CNC(=O)NC1=O)O |&1:1,2,3,7,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Pseudouridine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
β-Pseudouridine is the C-5 glycoside isomer of the nucleoside uridine. It is formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme. Pseudouridine is found in tRNAs from bacteria, archaea, and eukaryotes. In vitro, it reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner.
Verwenden
An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.
Definition
ChEBI: Pseudouridine is a C-glycosyl pyrimidine that consists of uracil having a beta-D-ribofuranosyl residue attached at position 5. The C-glycosyl isomer of the nucleoside uridine. It has a role as a fundamental metabolite.
Biochem/physiol Actions
Pseudouridine is essential for rRNA folding and for regulating translational accuracy and it is required for stabilizing the tRNA structure. Pseudouridine in rRNA and tRNA has been shown to fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation. Pseudouridine in snRNA has been shown to enhance spliceosomal RNA-pre-mRNA interaction to facilitate splicing regulation[1].
target
Human Endogenous Metabolite
Structure and conformation
Pseudouridine, being one of them, is the C5-glycoside isomer of uridine that contains a C-C bond between C1 of the ribose sugar and C5 of uracil, rather than usual C1-N1 bond found in uridine. The C-C bond gives it more rotational freedom and conformational flexibility.In addition, pseudouridine has an extra hydrogen bond donor at the N1 position.
Pseudouridine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[(1,1-dimethylethyl)diphenylsilyl]-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]-
D-Ribitol, 1,4-anhydro-1-C-(2,4-dimethoxy-5-pyrimidinyl)-, (1S)-
PSEUDOURIDINE NATURAL B ISOMER*FROM WHEAT BRAN
2,4(1H,3H)-Pyrimidinedione, 5-[2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]-
2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[(1,1-dimethylethyl)diphenylsilyl]-β-D-ribofuranosyl]-
5-O-(1-Methoxy-1-Methylethyl)-2,3-O-(1-Methylethylidene)-D-ribonic Acid γ-Lactone
PSEUDOISOCYTIDINE
D-Ribono-1,4-lacton
Downstream Produkte
Pseudouridine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 272)Lieferanten
1445-07-4()Verwandte Suche:
- 5-b-D-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione
- 5-β-D-ribofuranosyluracil
- BETA-PSEUDOURIDINE
- B-Pseudouridine
- 5-β-D-Ribofuranosyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
- 5-β-D-Ribofuranosylpyrimidine-2,4(1H,3H)-dione
- Pseudouridine C
- NSC 162405
- β-D-Pseudouridine
- 2,4(1H,3H)-PyriMidinedione, 5-b-D-ribofuranosyl-
- y-Uridine
- 2,4(1H,3H)-Pyrimidinedione, 5-β-D-ribofuranosyl-
- Uridine Impurity 20（β-Pseudouridine）
- Pseudourindine
- Pseudoruidine
- Pseudouridine, Beta-Pseudouridine, ψ
- PSEUDOURIDINE
- 5-Ribosyluracil
- β-Pseudouridine
- Pseudo-UTP
- 5-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
- Pseudouridine, natural antibiotics, RNA modified nucleosides
- Pseudouricdine
- 2,4(1H,3H)-Pyrimidinedione, 5-β-D-ribofuranosyl-
- Uridine Impurity 2 (Pseudouridine)
- 1445-07-4
- 445-07-4
- Bases & Related Reagents
- Carbohydrates & Derivatives
- Heterocycles
- Nucleotides
- Pharmaceutical
- Nucleosides
