NOCARDAMINE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Nocardamine is a ferrioxamine siderophore that has been found in
Streptomyces and has diverse biological activities. It chelates iron in a chrome azurol S assay (IC
50 = 9.9 μM). Nocardamine inhibits
M. smegmatis and
M. bovis biofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron. It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC
50s = 6, 18, 12, and 14 μM, respectively). Nocardamine also induces morphological changes in BM-N4 insect cells.
Verwenden
Nocardamine is a cyclic siderophore.
Definition
ChEBI: A cyclic hydroxamic acid siderophore that is produced by several bacterial species and exhibits antitumour activity.
NOCARDAMINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte