2-Hydroxychalkon
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- CAS-Nr.
- 644-78-0
- Bezeichnung:
- 2-Hydroxychalkon
- Englisch Name:
- 2-Hydroxychalcone
- Synonyma:
- o-Hydroxychalcone;2-HYDROXYCHALCONE;HYDROXYCHALCONE, 2-;2-Hydroxychalcone>SALICYLALACETOPHENONE;HYDROXYCHALCONE,2-(AS);2-Hydroxychalcone, 98+%;TRANS-2-HYDROXYCHALCONE;2-(2-HYDROXYBENZAL)ACETOPHENONE;2-Hydroxychalcone, 10 mM in DMSO
- CBNumber:
- CB7100356
- Summenformel:
- C15H12O2
- Molgewicht:
- 224.25
- MOL-Datei:
- 644-78-0.mol
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2-Hydroxychalkon Eigenschaften
- Schmelzpunkt:
- 144-150 °C(lit.)
- Siedepunkt:
- 396.3±34.0 °C(Predicted)
- Dichte
- 1.191±0.06 g/cm3(Predicted)
- pka
- 9.26±0.35(Predicted)
- Aggregatzustand
- powder
- Farbe
- Yellow
- BRN
- 2049134
- CAS Datenbank
- 644-78-0(CAS DataBase Reference)
2-Hydroxychalkon Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. It is also capable of inducing apoptosis by downregulating Bcl-2 levels and inhibiting the activation of NF-kB.
in vitro
2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells.
2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner.
Einzelnachweise
[1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72. DOI:
10.1016/j.cbi.2013.03.012[2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34. DOI:
10.1124/MOL.58.3.526[3]. Sonochemical Synthesis of 2’-Hydroxy-Chalcone Derivatives with Potential Anti-Oomycete Activity doi:
10.3390/antibiotics9090576
2-Hydroxychalkon Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Hydroxychalkon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 104)Lieferanten
644-78-0(2-Hydroxychalkon)Verwandte Suche:
- (E)-3-(2-HYDROXYPHENYL)-1-PHENYLPROP-2-EN-1-ONE
- HYDROXYCHALCONE, 2-
- 2-HYDROXYBENZYLIDENE ACETOPHENONE
- 2-(2-HYDROXYBENZAL)ACETOPHENONE
- 2-(2-HYDROXYBENZYLIDENE)ACETOPHENONE
- (2-Hydroxybenzylidene)acetophenone~3-(2-Hydroxyphenyl)-1-phenyl-2-propen-1-one
- 2-Hydroxychalcone, 98+%
- SALICYLALACETOPHENONE
- TRANS-2-HYDROXYBENZYLIDENEACETOPHENONE
- TRANS-2-HYDROXYCHALCONE
- 3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one
- o-Hydroxychalcone
- α-(o-Hydroxybenzylidene)acetophenone
- 2-(2-Hydroxybenzal)acetophenone
2-(2-Hydroxybenzylidene)acetophenone
Salicylalacetophenone
- 3-(2-hydroxyphenyl)-1-phenyl-2-propen-1-one
- 2-HYDROXYCHALCONE(UNSPECIFIEDISOMER)
- BENZYLIDENE-2-HYDROXYACETOPHENONE
- 2-Hydroxychalcone>
- 2-Propen-1-one, 3-(2-hydroxyphenyl)-1-phenyl-
- 2-HYDROXYCHALCONE
- inhibit,Inhibitor,Apoptosis,Nuclear factor-κB,Nuclear factor-kappaB,NF-κB,TNBC,2 Hydroxychalcone,2-Hydroxychalcone,Bcl-2 Family,2Hydroxychalcone
- HYDROXYCHALCONE,2-(AS)
- 2-Hydroxychalcone, 10 mM in DMSO
- 644-78-0
- Ketones
- Organic Building Blocks
- Carbonyl Compounds
- C15 to C38
- Building Blocks
- Chalcones, etc. (Building Blocks for Liquid Crystals)
- Flavonoids
- Building Blocks for Liquid Crystals
- Biochemistry
- Building Blocks for Liquid Crystals
- Chalcones, etc. (Building Blocks for Liquid Crystals)
- Flavonoids
- Functional Materials
- Chalcones
