Tetrahydrouridine
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- CAS-Nr.
- 18771-50-1
- Englisch Name:
- Tetrahydrouridine
- Synonyma:
- nsc-112907;nsc-112907-d;DFMA | RMI 71897;TETRAHYDROURIDINE;3,4,5,6-tetrahydrouridine;Tetrahydrouridine dihydrate;Uridine, 3,4,5,6-tetrahydro-;3,4,5,6-Tetrahydrouridine (>3,4,5,6-Tetrahydrouridine (>80%);Tetrahydrouridine (aqueous solution)
- CBNumber:
- CB6748654
- Summenformel:
- C9H16N2O6
- Molgewicht:
- 248.23
- MOL-Datei:
- 18771-50-1.mol
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Tetrahydrouridine Eigenschaften
- Schmelzpunkt:
- >195°C (dec.)
- Siedepunkt:
- 668.6±55.0 °C(Predicted)
- Dichte
- 1.622±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- L?slichkeit
- Methanol (Slightly), Water (Slightly)
- Aggregatzustand
- Solid
- pka
- 12.50±0.40(Predicted)
- Farbe
- White to Off-White
- Stabilit?t:
- Light Sensitive
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Tetrahydrouridine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Tetrahydrouridine is a competitive, reversible inhibitor of cytidine deaminase (K
i values = 54 and 240 nM for human and
E. coli enzymes, respectively). Its use, alone or in combination with the DNA methyltransferase inhibitor 5-fluoro-2’-deoxycytidine, is being evaluated in animal models and clinical trials for diseases, including cancer and mitochondrial DNA depletion syndrome.
Verwenden
3,4,5,6-Tetrahydrouridine, is a derivative of Uridine (U829910). Tetrahydrouridine (THU), is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.
Tetrahydrouridine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tetrahydrouridine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 91)Lieferanten
18771-50-1()Verwandte Suche:
- 3,4,5,6-Tetrahydrouridine (>80% by HPLC)
- (4S)-3,4,5,6-Tetrahydro-4β-hydroxy-1-(β-D-ribofuranosyl)pyrimidin-2(1H)-one
- 3,4,5,6-tetrahydrouridine
- nsc-112907
- nsc-112907-d
- tetrahydro-4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyrimidinon
- TETRAHYDROURIDINE
- Uridine, 3,4,5,6-tetrahydro-
- 3,4,5,6-Tetrahydrouridine (>
- Tetrahydrouridine dihydrate
- 3,4,5,6-Tetrahydrouridine (>80%)
- Uridine Impurity 27（Tetrahydrouridine）
- 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one
- DFMA | RMI 71897
- Tetrahydro uridineQ: What is
Tetrahydro uridine Q: What is the CAS Number of
Tetrahydro uridine Q: What is the storage condition of
Tetrahydro uridine Q: What are the applications of
Tetrahydro uridine
- Tetrahydrouridine (aqueous solution)
- Tetrahydrouridine, cytidine deaminase inhibitor
- Tetrahydrouridine (aqueous solution), cytidine deaminase inhibitor
- 18771-50-1
