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5,11-Dimethyl-6H-pyrido[4,3-b]carbazol

ELLIPTICINE Struktur
519-23-3
CAS-Nr.
519-23-3
Bezeichnung:
5,11-Dimethyl-6H-pyrido[4,3-b]carbazol
Englisch Name:
ELLIPTICINE
Synonyma:
K00071;icig770;CP-3025;LP00531;CS-1794;CCG36483;NSC-71795;CCG 36483;CCG-36483;DB-052047
CBNumber:
CB6746832
Summenformel:
C17H14N2
Molgewicht:
246.31
MOL-Datei:
519-23-3.mol

5,11-Dimethyl-6H-pyrido[4,3-b]carbazol Eigenschaften

Schmelzpunkt:
316-318°C
Siedepunkt:
379.31°C (rough estimate)
Dichte
1.257±0.06 g/cm3 (20 ºC 760 Torr)
Brechungsindex
1.5794 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
L?slichkeit
DMSO: soluble
Aggregatzustand
Bright yellow solid
pka
16.59±0.40(Predicted)
Farbe
Light yellow to yellow
Merck 
13,3581
LogP
4.800
CAS Datenbank
519-23-3(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 25
S-S?tze: 45
RIDADR  UN 3462 6.1/PG 3
WGK Germany  3
RTECS-Nr. UU8825000
HazardClass  6.1(b)
PackingGroup  III
Toxizit?t LD50 in mice (mg/kg): 19.5-22.4 i.v.; 178-204 orally (Rakieten)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

5,11-Dimethyl-6H-pyrido[4,3-b]carbazol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R25:Giftig beim Verschlucken.

S-S?tze Betriebsanweisung:

S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Ellipticine is an alkaloid isolated from Apocyanaceae plants that exhibits antitumor activities by intercalating into DNA and/or inhibiting DNA topoisomerase II. It forms covalent adducts in DNA after being enzymatically activated with cytochrome P450 isoforms (e.g., CYP3A4, CYP1A1, or CYP1A2) or by peroxidases in target tissues. Ellipticine has been shown to inhibit the proliferation of human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells, and U87MG glioblastoma cells with IC50 values ranging from 0.27-4.7 μM.

Definition

ChEBI: A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.

Allgemeine Beschreibung

A topoisomerase II inhibitor. Acts as an intercalative alkaloid that stimulates topoisomerase II-mediated DNA breakage. Is also capable of uncoupling mitochondrial oxidative phosphorylation.

l?uterung methode

This DNA intercalator is purified by recrystallisation from CHCl3 or MeOH and is dried in vacuo. The UV max values in aqueous EtOH/HCl are at 241, 249, 307, 335 and 426nm. [Marini-Bettolo & Schmutz Helv Chim Acta 42 2146 1959.] The methiodide has m 360o(dec), with UV (EtOH/KOH) at 223, 242, 251, 311, 362 and 432nm. [Goodwin et al. J Am max Chem Soc 81 1903 1959, Beilstein 23/9 V 417.]

5,11-Dimethyl-6H-pyrido[4,3-b]carbazol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


5,11-Dimethyl-6H-pyrido[4,3-b]carbazol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 121)Lieferanten
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519-23-3(5,11-Dimethyl-6H-pyrido[4,3-b]carbazol)Verwandte Suche:


  • ELLIPTICINE
  • 5,11-DIMETHYLPYRIDO[4,3-B]CARBAZOLE
  • 5,11-DIMETHYLPYRIDO[4.3:B]CARBAZOLE
  • 5,11-DIMETHYL-6H-PYRIDO[4,3-B]CARBAZOLE
  • 3-b)carbazole,5,11-dimethyl-6h-pyrido(
  • icig770
  • ELLIPTICINE, FOR FLUORESCENCE
  • ELLIPTICINE(RG)
  • ELLIPTICIN
  • PYRIDO(4,3-B)CARBAZOLE,5,11-DIMETHYL-
  • CP-3025
  • NSC-71795
  • Ellipticine Solution
  • 33668-12-1 (Hydrochloride)
  • 55042-50-7 (Tartrate)
  • 6H-Pyrido(4,3-B)carbazole, 5,11-dimethyl-
  • Brn 0221300
  • Ccris 2003
  • Ellipticine,5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
  • 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole Ellipticine
  • Ellipticine, ≥99%
  • CCG 36483
  • CCG36483
  • CCG-36483
  • CCG-36483; CCG36483; CCG 36483; BRN-0221300; BRN0221300; BRN 0221300; DB-052047; K00071; LP00531; LS-133282; NSC 71795; NSC71795; NSC-71795; TCMDC-125546; VZ29809. ELLIPTECINE; ELLIPTICINE; ELLIPTISINE
  • DB-052047
  • Elliptisine
  • K00071
  • LP00531
  • LS-133282
  • TCMDC-125546
  • VZ29809. elliptecine
  • CS-1794
  • Ellipticine - CAS 519-23-3 - Calbiochem
  • Ellipticine,Inhibitor,NSC71795,NSC-71795,Topoisomerase,inhibit
  • Ellipticine, 10 mM in DMSO
  • 519-23-3
  • DNA metabolism
  • Fluorescent Probes, Labels, Particles and Stains
  • Fluorescent Stains
  • Nucleic Acid Stains
  • Nucleic Acid Stains For Flow Cytometry
  • DNA Repair Regulators
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Apoptosis and Cell Cycle
  • Biochemicals and Reagents
  • BioChemical
  • Inhibitors
  • Alkaloids
  • Indoles and derivatives
  • Antitumour
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