β-Elemonic Acid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
β-Elemonic acid is a triterpene isolated from
Boswellia (
Burseraceae) that exhibits anticancer activity. It inhibits growth of non-small cell lung cancer (NSCLC) A549 cells (IC
50 = 6.92 μM)
in vitro. β-Elemonic acid induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner but has no effect on normal epithelial WI-38 cells. It inhibits phosphorylation of p42/44, MAPK/JNK, and p38 and induces production of reactive oxygen species (ROS) and COX-2 expression
in vitro. β-Elemonic acid also inhibits prolyl endopeptidase (IC
50 = 39.74 μM)
in vitro.
Verwenden
β-Elemonic Acid inhibits cell proliferation of human lung adenocarcinoma A549 cells and role of MAPK, ROS activation and glutathione depletion. Elemonic acid is also a Pin1 inhibitors.
β-Elemonic Acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte