Guanosin, 8-Brom-, zyklisches 3',5'-(Hydrogen-phosphat), Mononatriumsalz Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
8-bromo-Cyclic GMP (8-bromo-cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase. At 1 μM-0.1 mM, 8-bromo-cGMP can inhibit acetylcholine-induced increases in intracellular calcium concentrations.
Chemische Eigenschaften
White powder
Biologische Aktivit?t
Membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1 α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro .
Guanosin, 8-Brom-, zyklisches 3',5'-(Hydrogen-phosphat), Mononatriumsalz Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte