MIBEFRADIL Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Posicor was launched in Argentina, Azerbaijan, Brazil, the Chile, Czech Republic, Denmark, Germany, Ireland, Kazakhstan, the Netherlands, Norway, Peru, the Philippines, Switzerland, Thailand, Turkmenistan, the UK, the US and Venezuela for use in hypertension. It can be assembled in five steps from 4-(1-benzyloxy-Nmethylformamido) butyric acid with o-phenylenediamine and isobutylchloroformate. Posicor binds to calcium channels in a manner that overlaps the Verapamil, SR-33557 and Diltiazem binding site without effecting the dihydropyridine binding site. Thus it blocks a wide variety of calcium channels with selectivity for T-type followed sequentially by L-type. There is also some calcium agonist activity along with sodium and potassium channel activity. It is chemically distinct from the other calcium antagonists (first member of a new catagory of tetralol calcium antagonists). It has the ability to lower heart rate with no negative inotropic effects and is as effective as Amlodipine and more effective than Diltiazem for the treatment of mild to moderate hypertension. Serious drug interactions are possible because Posicor inhibits both CYP2D6 and CYP3A4.

Verwenden

Mibefradil has been used as a T-type calcium channel blocker in various cells. It has also been used to reduce apoptosis of retinal ganglion cells (RGC) in EphB2-Fc.

MIBEFRADIL Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

MIBEFRADIL Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7724	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9310	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	988	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58

116666-63-8()Verwandte Suche:

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• [(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methyl-amino]ethyl]-6-fluoro-1-isopropyl-tetralin-2-yl] 2-methoxyacetate dihydrochloride
• MIBEFRADIL
• Mibefradil diHCl
• (1S,2S)-2-[2[[3-(2-Benzimidazolyl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate dihydrochloride hydrate
• (1s-cis)-orid
• 2-(2-((3-(1h-benzimidazol-2-yl)propyl)methylamino)ethyl)-aceticaci
• 6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenylester,dihydrochl
• ro40-5967/001
• Mibefradil hydrate dihydrochloride
• Ro 40-5967 hydrate, (1S,2S)-2-[2[[3-(2-Benzimidazolylpropyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate hydrate dihydrochloride
• Acetic acid, methoxy-, 2-(2-((3-(1H-benzimidazol-2-yl)propyl)methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, dihydrochloride, (1S-cis)-
• Mibefradil HCl
• Mibefradil dihydrochloride hydrate
• Ro 40-5967 hydrate
• Mibefradil(Ro 40-5967)
• Mibefradil (hydrochloride)
• Mibefradil 2HCl
• Ro 40-5967 (dihydrochloride)
• MIBEFRADIL USP/EP/BP
• CS-1455
• Mibefradil 2Hcl(Ro 40-5967)
• Mibefradil dihydrochloride,inhibit,Calcium Channel,Mibefradil,Ro 40-5967,Inhibitor,Ca channels,Ca2+ channels
• 116666-63-8
• C29H38FN3O32HCl
• C29H40Cl2FN3O3