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Dolutegravir 2-Desfluoro Impurity

Dolutegravir 2-Desfluoro Impurity Struktur
1863916-88-4
CAS-Nr.
1863916-88-4
Englisch Name:
Dolutegravir 2-Desfluoro Impurity
Synonyma:
4-Fluoro Dolutegravir;Dolutegravir Impurity G;Dolutegravir Impurity 50;Dolutegravir Impurity 47;Dolutegravir 4-Fluoro Impurity;Dolutegravir 2-Desfluoro Impurity;(4R,12aS)-N-(4-fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(4-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-;2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(4-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-/Dolutegravir impurity;Dolutegravir impurity 4/Defluoro Dolutegravir/(4R,12aS)-N-(4-Fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
CBNumber:
CB64796145
Summenformel:
C20H20FN3O5
Molgewicht:
401.39
MOL-Datei:
1863916-88-4.mol

Dolutegravir 2-Desfluoro Impurity Eigenschaften

Siedepunkt:
675.7±55.0 °C(Predicted)
Dichte
1.49±0.1 g/cm3(Predicted)
L?slichkeit
DMSO (Slightly), Methanol (Slightly, Heated)
Aggregatzustand
Solid
pka
4.50±1.00(Predicted)
Farbe
Off-White to Light Brown

Sicherheit

Dolutegravir 2-Desfluoro Impurity Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Defluoro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Dolutegravir 2-Desfluoro Impurity Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dolutegravir 2-Desfluoro Impurity Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 31)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
CR Corporation Limited
+8613062833949
fred.wen@crcorporation.cn China 8647 58
sgtlifesciences pvt ltd
+8617013299288
dj@sgtlifesciences.com China 12373 58
China National Standard Pharmaceutical Corporation Limited
+8615391658522
overseasales@yongstandards.com China 11922 58
ShenZhen H&D Pharmaceutical Technology Co., LTD
+8618627948422
sale@hdimpurity.com China 3389 58
Moxin Chemicals
+8617320513646
mike@molcoo.com China 9457 58
Shenzhen Roark Pharma-Tec Co., Ltd. 13128912434
2880126944@qq.com China 2577 58
Beijing Comparison Pharmaceutical Technology Co., Ltd 010-010-52878169 15801002657
sales@bjcomparison.com China 5004 58
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396
sales@chem-strong.com China 18070 56
Shanghai CR Corporation Limited 021-80270511; 4006653949
fred.wen@crcorporation.cn China 10044 58
Guangzhou Jiuzhi Pharmaceutical Technology Co., Ltd. 020-89854820
sales@jzpharma.cn China 1130 58

  • 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(4-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-/Dolutegravir impurity
  • Dolutegravir impurity 4/Defluoro Dolutegravir/(4R,12aS)-N-(4-Fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
  • Dolutegravir Impurity G
  • Dolutegravir 2-Desfluoro Impurity
  • 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(4-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-
  • (4R,12aS)-N-(4-fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
  • Dolutegravir Impurity 47
  • Dolutegravir Impurity 50
  • 4-Fluoro Dolutegravir
  • Dolutegravir 4-Fluoro Impurity
  • 1863916-88-4
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