UPCDC30245
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- CAS-Nr.
- 1883351-01-6
- Englisch Name:
- UPCDC30245
- Synonyma:
- UPCDC30245;UPCDC30245 >=98% (HPLC);1-Piperazineethanamine, N-[1-[3-(5-fluoro-1H-indol-2-yl)phenyl]-4-piperidinyl]-4-(1-methylethyl)-
- CBNumber:
- CB64670658
- Summenformel:
- C28H38FN5
- Molgewicht:
- 463.63
- MOL-Datei:
- 1883351-01-6.mol
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UPCDC30245 Eigenschaften
- Siedepunkt:
- 647.6±55.0 °C(Predicted)
- Dichte
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 16.22±0.30(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
UPCDC30245 Chemische Eigenschaften,Einsatz,Produktion Methoden
Biochem/physiol Actions
UPCDC30245 is an allosteric inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). p97 is an integral component of the ubiquitin fusion degradation (UFD) pathway. It plays a role in degradation of misfolded proteins, Golgi membrane reassembly, membrane transport, myofibril assembly, autophagosome maturation, and cell division, and is overexpressed in many tumor types. UPCDC30245 has an IC50 value of 27 nM, and has been shown to bind at the junction between the D1 and D2 domains of p97. UPCDC30245 has been used in cryo-ECM to show how such inhibitor binding prevents the confomational changes necessary for p97 function.
UPCDC30245 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
UPCDC30245 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 8)Lieferanten
- UPCDC30245
- UPCDC30245 >=98% (HPLC)
- 1-Piperazineethanamine, N-[1-[3-(5-fluoro-1H-indol-2-yl)phenyl]-4-piperidinyl]-4-(1-methylethyl)-
- 1883351-01-6
