RP 001 (hydrochloride) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

RP 001 is a potent sphingosine-1-phosphate receptor 1 (S1P₁) agonist (EC₅₀ = 9 pM). It is competitive with W146 , a selective S1P₁ antagonist, and induces internalization and polyubiquitination of S1P₁ in a dose-dependent manner. RP 001 induces dose-dependent lymphopenia in mice (EC₅₀ = 0.03 mg/kg). It reduces S1P₁-EGFP expression ex vivo on lymphocytes in the isolated lymph node of Edg1^eGFP/eGFP mice but has no effect in vivo. RP 001 also completely inhibits M. stadtmanae (MSS) rechallenge-induced enlargement of B cell-rich tertiary lymphoid tissues (TLTs) and reduces neutrophil accumulation in the airways of a mouse model of experimental hypersensitivity pneumonitis.

Verwenden

RP 001 Hydrochloride is a picomolar, short-acting S1P1 agonist.

RP 001 (hydrochloride) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

RP 001 (hydrochloride) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8617	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19704	58

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• RP001 hydrochloride,RP 001 hydrochloride
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• 1781880-34-9