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B581

B581 Struktur
149759-96-6
CAS-Nr.
149759-96-6
Englisch Name:
B581
Synonyma:
FTASE INHIBITOR I;B581;B581 USP/EP/BP;H-Cys-()-Val-()-Phe-Met-OH;CYS-((R))-VAL-((R))-PHE-MET;H-CYS-(R)-VAL-(R)-PHE-MET-OH;H-Cys-psi(CH2NH)Val-psi(CH2NH)Phe-Met-OH;N-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-me;H-Cys-psi(CH2NH)Val-psi(CH2NH)Phe-Met-OH trifluoroacetate salt;N-[2(S)-[2(R)-AMINO-3-MERCAPTOPROPYLAMINO]-3-METHYL-BUTYL]-PHE-MET
CBNumber:
CB6454713
Summenformel:
C22H38N4O3S2
Molgewicht:
470.69
MOL-Datei:
149759-96-6.mol

B581 Eigenschaften

Siedepunkt:
716.1±60.0 °C(Predicted)
Dichte
1.161±0.06 g/cm3(Predicted)
storage temp. 
−20°C
L?slichkeit
H2O: soluble
Aggregatzustand
solid
pka
3.04±0.10(Predicted)
Farbe
white

Sicherheit

S-S?tze: 22-24/25
WGK Germany  3

B581 Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

FTase inhibitor I is a potent inhibitor of farnesyltransferase (FTase; IC50 = 21 nM) that is greater than 30-fold selective for FTase over geranylgeranyl transferase (GGTase; IC50 = 790 nM). It prevents farnesylation of Ras and inhibits proliferation of cells transformed by Ras farnesylation. In a dog model of subarachnoid hemorrhage, it reduces GTP-Ras in spastic basilar arteries, decreases angiographic vasospasm, and improves clinical scores.

Verwenden

FTase Inhibitor I is a potent, selective, peptidomimetic FTase inhibitor.

Definition

ChEBI: A dipeptide obtained from the tetrapeptide Cys-Val-Phe-Met by reduction of the amide carbonyl groups of the Cys and Val residues.

Enzyminhibitor

This cell-permeable CAAX peptidomimetic (FW = 470.70 g/mol; FWtrifluoracetate-salt = 583.71 g/mol; CAS 149759-96-6), named as N-[2(S)- (2(R)-2-amino-3-mercaptopropylamino)-3-methylbutyl]-L-phenylalanyl-L methionine), binds to and prevents protein farnesyltransferase (IC50 = 21 nM) from interacting with C-terminal L-Cys-L-Val-L-Phe-L-Met substrate recognition sequences that are present in its natural substrates. Otherwise hydrophilic proteins associate with membranes by means of enzymatic attachment of hydrophobic moieties to their C-termini. Whereas prenylation occurs in the cytosol, post-prenylation processing is accomplished on the cytoplasmic surface of the endoplasmic reticulum and Golgi apparatus. B581 inhibits prenylation and processing of H-ras and lamin A. B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation.

B581 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


B581 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 77)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Alpha Biopharmaceuticals Co., Ltd
+86-15542445688
sales@alabiochem.com China 888 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32079 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22883 58
Nextpeptide Inc
+86-0571-81612335 +8613336028439
sales@nextpeptide.com China 19908 58
Nanjing TGpeptide
+86-13347807150 +86-13347807150
support@tgpeptide.com China 3279 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52925 58
Changsha MOL Changes Biotechnology Co., Ltd.
+8619375158599
info@molchanges.com China 5225 58
Alabiochem Tech.Co., Ltd. 0512-58900862 400-0707518
sales@alabiochem.com China 995 59

149759-96-6()Verwandte Suche:


  • CYS-((R))-VAL-((R))-PHE-MET
  • H-CYS-(R)-VAL-(R)-PHE-MET-OH
  • B581
  • N-[(S)-2-((R)-2-AMINO-3-MERCAPTO-PROPYLAMINO)-3-METHYL-BUTYL]-PHE-MET-OH
  • N-[2(S)-(2(R)-2-AMINO-3-MERCAPTOPROPYLAMINO)-3-METHYLBUTYL]-L-PHENYLALANYL-L-METHIONINE
  • N-[2(S)-[2(R)-AMINO-3-MERCAPTOPROPYLAMINO]-3-METHYL-BUTYL]-PHE-MET
  • N-[2(S)-[2(R)-AMINO-3-MERCAPTOPROPYLAMINO]-3-METHYLBUTYL]-PHE-MET-OH
  • N-[(S)-2-((R)-2-AMino-3-Mercapto-propylaMino)-3-Methyl-butyl]-Phe-Met-OH, B581
  • (2S)-2-({(2S)-2-[((2S)-2-{[(2R)-2-aMino-3-sulfanylpropyl]aMino}-3-Methylbutyl)aMino]-3-phenylpropanoyl}aMino)-4-(Methylsulfanyl)butanoic acid
  • H-Cys-()-Val-()-Phe-Met-OH
  • N-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-me
  • N-[2(S)-(2(R)-2-Amino-3-mercaptopropylamino)-3-methylbutyl]-L-phenylalanyl-L-methionine trifluoroacetate salt
  • H-Cys-psi(CH2NH)Val-psi(CH2NH)Phe-Met-OH
  • H-Cys-psi(CH2NH)Val-psi(CH2NH)Phe-Met-OH trifluoroacetate salt
  • L-Methionine, N-[(2S)-2-[[(2R)-2-amino-3-mercaptopropyl]amino]-3-methylbutyl]-L-phenylalanyl-
  • B581 USP/EP/BP
  • FTASE INHIBITOR I
  • 149759-96-6
  • C22H38N4O3S2
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • G Proteins and Cyclic Nucleotides
  • G Protein Function
  • Post-translational Modification
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