SCUTELLAREIN Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Scutellarein is a flavone that has been isolated from
S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities. It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml. Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC
50s = 12 and 0.86 μM, respectively). It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM.
In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.
Chemische Eigenschaften
Yellow solid
Verwenden
Scutellarein is a flavonoid that can be found in Scutellaria lateriflora. Scutellarein is a hydrolysis product of Scutellarein (S201900), its glucuronide conjugated analogue.
Definition
ChEBI: Flavone substituted with hydroxy groups at C-4', -5, -6 and -7.
SCUTELLAREIN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
