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XE 991 dihydrochloride

XE 991 dihydrochloride Struktur
122955-13-9
CAS-Nr.
122955-13-9
Englisch Name:
XE 991 dihydrochloride
Synonyma:
XE 991 HCl;blocks M current;XE991 HCl (LS190926);XE 991 (hydrochloride);XE 991 dihydrochloride, 10 mM in DMSO;XE-991 dihydrochloride，KCNQ channel blocker;XE-991 dihydrochloride, KCNQ channel blocker;10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;10,10-bis(pyridin-4-ylmethyl)anthracen-9-one:dihydrochloride;10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride
CBNumber:
CB63146404
Summenformel:
C26H21ClN2O
Molgewicht:
412.92
MOL-Datei:
122955-13-9.mol

XE 991 dihydrochloride Eigenschaften

storage temp. 
Store at -20°C
L?slichkeit
DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 2 mg/mL
Aggregatzustand
Powder
Farbe
Off-white to light yellow
Wasserl?slichkeit
Soluble to 100 mM in water

Sicherheit

XE 991 dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The KCNQ potassium channels are neuronal modulators which combine with other KQT or KCNE channels to form heteromultimers. XE 991 is a blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC50 = 0.75 and 0.71 μM, respectively) as well as KCNQ2+3 heteromultimers (IC50 = 0.6 μM). It much less effectively blocks eag, erg, and elk channels. The effectiveness of XE 991 against KCNQ channels depends on partners or accessory proteins. Through these actions, XE 991 enhances acetylcholine release from rat brain slices (EC50 = 490 nM) and shows good in vivo potency and duration of action, suggesting utility in Alzheimer’s disease therapeutics. While early studies focused on actions in the central nervous system, XE 991 can be used to explore the roles of KCNQ channels in neuronal regulation throughout the body.

Verwenden

XE 991 dihydrochloride is a potent & selective inhibitor of KCNQ voltage-gated K-channels.

XE 991 dihydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

XE 991 dihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 50)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
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InvivoChem 		+1-708-310-1919 +1-13798911105
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Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
Aladdin Scientific
tp@aladdinsci.com United States 57505 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4589 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9804 58
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994
 2853530910@QQ.com China 8011 62
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720
 lucy@atkchemical.com China 9987 58
  • XE 991 (hydrochloride)
  • 10,10-bis(pyridin-4-ylmethyl)anthracen-9-one:dihydrochloride
  • 10,10-bis(pyridin-4-ylmethyl)anthracen-9-one
  • XE991 HCl (LS190926)
  • XE991,inhibit,XE 991 dihydrochloride,KcsA,XE 991,XE-991,Inhibitor,Potassium Channel
  • XE 991 HCl
  • 10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride
  • blocks M current
  • XE-991 dihydrochloride, KCNQ channel blocker
  • XE-991 dihydrochloride，KCNQ channel blocker
  • XE 991 dihydrochloride, 10 mM in DMSO
  • 122955-13-9
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