VLX1570
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VLX1570 Eigenschaften
- storage temp.
- Store at -20°C
- L?slichkeit
- DMF:25.0(Max Conc. mg/mL);53.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.64(Max Conc. mM)
DMSO:47.0(Max Conc. mg/mL);100.13(Max Conc. mM)
- Aggregatzustand
- A crystalline solid
- Farbe
- Light yellow to yellow
Sicherheit
VLX1570 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
VLX1570 is an inhibitor of 19S proteasomal deubiquitinases with IC50 values of 6.4 and 13 μM for deubiquitinase activity in vitro using Ub-rhodamine and Ub-AMC, respectively, as substrates. It is selective for proteasomal deubiquitinases over a panel of deubiquitinases at 20 μM, but inhibits USP5 by greater than 50%, and over a panel of 211 kinases at 10 μM, but inhibits Cdk4 by 77%. VLX1570 binds to and inhibits recombinant ubiquitin-specific protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) in vitro, and inhibits the USP14 and UCHL5 activity of purified 19S proteasomes when used at a concentration of 50 μM. It inhibits the proliferation of KMS-11, RPMI-8226, OPM-2, and OPM-2-BZR multiple myeloma cells (IC50s = 43, 74, 126, and 191 nM, respectively), as well as induces apoptosis and increases the accumulation of polyubiquitinated proteins. VLX1570 (3 mg/kg per day for 10 days) increases survival and reduces tumor growth in KMS-11-LUC2 and RPMI-8226 mouse xenograft models, respectively.Verwenden
VLX1570 is a proteasome deubiquitinase inhibitor. It also exhibits antineoplastic activities.VLX1570 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
VLX1570 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 67)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32951 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32079 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6312 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10473 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 24727 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49734 | 58 |
TargetMol Chemicals Inc. | |
support@targetmol.com | United States | 38469 | 58 |
Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 |
kathy@hbyinsheng.com | China | 3512 | 58 |
Aceschem Inc. | +1-817863-6948 +1-(817)863-6948 |
sales@aceschem.com | United States | 19632 | 58 |
- VLX1570
- CS-2226
- VLX1570 (VLX 1570
- 4H-Azepin-4-one, 3,5-bis[(4-fluoro-3-nitrophenyl)methylene]hexahydro-1-(1-oxo-2-propen-1-yl)-
- (3Z,5Z)-1-Acryloyl-3,5-bis(4-fluoro-3-nitrobenzylidene)azepan-4-one
- 1-Acryloyl-3,5-bis(4-fluoro-3-nitrobenzylidene)azepan-4-one
- VLX1570,Inhibitor,Deubiquitinase,VLX-1570,DUBs,VLX 1570,inhibit
- (3E,5E)-1-Acryloyl-3,5-bis(4-fluoro-3-nitrobenzylidene)hexahydro-4H-azepin-4-one
- 1-acryloyl-3,5-bis((E)-4-fluoro-3-nitrobenzylidene)azepan-4-one
- 1431280-51-1
- C23H17F2N3O6