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2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid

2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Struktur
1572936-83-4
CAS-Nr.
1572936-83-4
Englisch Name:
2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
Synonyma:
Cl-Channels,inhibit,MONNA,Inhibitor,Chloride Channel;2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid;2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid;Benzoic acid, 2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-
CBNumber:
CB63049204
Summenformel:
C18H14N2O5
Molgewicht:
338.31
MOL-Datei:
1572936-83-4.mol

2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Eigenschaften

Siedepunkt:
553.1±50.0 °C(Predicted)
Dichte
1.421±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: slightly soluble
Aggregatzustand
A crystalline solid
pka
2.26±0.22(Predicted)
Farbe
Brown to dark brown

Sicherheit

2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 μM in Xenopus oocytes), a calcium-activated chloride channel (CaCC). It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 μM. MONNA (10 μM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride. It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.

Verwenden

2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid selectively inhibits the calcium-activated chloride channel, anoctamin-1. 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid has potential applications for developing treatments for hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.

2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
  • 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
  • Benzoic acid, 2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-
  • Cl-Channels,inhibit,MONNA,Inhibitor,Chloride Channel
  • 1572936-83-4
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