Dynasore hydrate
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- CAS-Nr.
- 1202867-00-2
- Englisch Name:
- Dynasore hydrate
- Synonyma:
- Dynasore hydrate
;N'-(3,4-Dihydroxybenzylidene)-3-hydroxy-2-naphthohydrazide hydrate(1:x)
- CBNumber:
- CB62750338
- Summenformel:
- C18H16N2O5
- Molgewicht:
- 340.33004
- MOL-Datei:
- 1202867-00-2.mol
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Dynasore hydrate
Eigenschaften
- storage temp.
- -20°C
- L?slichkeit
- DMSO: ≥10mg/mL
- Aggregatzustand
- powder
- Farbe
- off-white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
N |
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| R-S?tze: |
50 |
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| S-S?tze: |
22-24/25-61 |
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| RIDADR |
UN 3077 9 / PGIII |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H400 |
Sehr giftig für Wasserorganismen. |
Kurzfristig (akut) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
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Dynasore hydrate
Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Dynasore hydrate has been used:
- for priming fetal mesenchymal stem/stromal cells (fMSC)
- in confocal microscopy
- in wound healing/scratch and tube-formation assay
- to analyse its effects on Coxsackievirus A9 (CAV9) infection
- to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis
- in live imaging of cells
Allgemeine Beschreibung
Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.
Biochem/physiol Actions
Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.
Dynasore hydrate
Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Dynasore hydrate
Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 4)Lieferanten
- Dynasore hydrate
- N'-(3,4-Dihydroxybenzylidene)-3-hydroxy-2-naphthohydrazide hydrate(1:x)
- 1202867-00-2
