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7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide

7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide Struktur
1236199-60-2
CAS-Nr.
1236199-60-2
Englisch Name:
7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide
Synonyma:
CS-2555;EDO-S101;Minomustine;Tinostamustine(EDO-S101);EDO-S101;EDO S101;EDOS101;EDO-S101?(Tinostamustine);Histone deacetylases,Inhibitor,EDO-S101,EDOS101,inhibit,EDO S101,HDAC,EDO-S-101;1H-Benzimidazole-2-heptanamide, 5-[bis(2-chloroethyl)amino]-N-hydroxy-1-methyl-;7-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzodiazol-2-yl}-N-hydroxyheptanamide;7-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)-N-hydroxyheptanamide
CBNumber:
CB62735711
Summenformel:
C19H28Cl2N4O2
Molgewicht:
415.36
MOL-Datei:
1236199-60-2.mol

7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide Eigenschaften

Dichte
1.27±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
L?slichkeit
DMSO:14.0(Max Conc. mg/mL);33.71(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);4.82(Max Conc. mM)
Aggregatzustand
A crystalline solid
pka
9.48±0.20(Predicted)
Farbe
White to off-white

Sicherheit

7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

EDO-S101 is a fusion molecule composed of the DNA alkylating agent bendamustine and the histone deacetylase (HDAC) inhibitor SAHA that inhibits class I and II HDACs (IC50s = 9-107 nM for HDAC1-3, 6, 8, and 10). It inhibits HDAC activity in rat peripheral blood mononuclear cells (PBMCs) ex vivo by 90% following a single dose of 10 mg/kg. EDO-S101 also induces formation of DNA crosslinks and double-strand breaks in HL-60 cells. It reduces growth of multiple myeloma (MM) cell lines irrespective of p53 mutational status or established resistance to DNA alkylating agents (IC50s = 1.6-4.8 μM). EDO-S101 also induces MM cell death ex vivo in bone marrow samples isolated from patients with early- and late-stage MM. In vivo, EDO-S101 (60 mg/kg per week) reduces tumor growth and prolongs survival in an MM1S end-stage mouse xenograft model. It also prolongs survival in a multidrug resistant Vk12653 mouse transplant model of refractory MM.

7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 52)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
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InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581
 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38460 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Acesys Pharmatech 18860950986
 tangmanman@zenjipharma.com China 1733 55
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4456 55
Shanghai Send Pharmaceutical Technology Co., Ltd. 021-58088081 Q3382968513
 danping@shsendpharm.com China 3117 55
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994
 2853530910@QQ.com China 8014 62
  • 7-(5-(1,5-dichloropentan-3-yl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)-N-hydroxyheptanaMide
  • EDO-S101
  • Minomustine
  • Tinostamustine(EDO-S101)
  • CS-2555
  • EDO-S101;EDO S101;EDOS101
  • 7-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzodiazol-2-yl}-N-hydroxyheptanamide
  • 7-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)-N-hydroxyheptanamide
  • 1H-Benzimidazole-2-heptanamide, 5-[bis(2-chloroethyl)amino]-N-hydroxy-1-methyl-
  • Histone deacetylases,Inhibitor,EDO-S101,EDOS101,inhibit,EDO S101,HDAC,EDO-S-101
  • EDO-S101?(Tinostamustine)
  • 1236199-60-2
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