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Umbralisib

Umbralisib Struktur
1532533-67-7
CAS-Nr.
1532533-67-7
Englisch Name:
Umbralisib
Synonyma:
CS-2443;TGR1205;RP-5264;TGR-1202;Umbralisib;RP-5264 TGR-1202;RP5264;UMBRALISIB;TGR-1202(Umbralisib);Umbralisib (TGR-1202);RP5264; TGR1202; TGR 1202; RP-5264; RP 5264
CBNumber:
CB62716383
Summenformel:
C31H24F3N5O3
Molgewicht:
571.55
MOL-Datei:
1532533-67-7.mol

Umbralisib Eigenschaften

Siedepunkt:
737.4±60.0 °C(Predicted)
Dichte
1.43±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMF: 1 mg/ml; DMSO: 1 mg/ml
Aggregatzustand
solid
pka
3.79±0.30(Predicted)
Farbe
White to off-white

Sicherheit

Umbralisib Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Umbralisib (TGR-1202) tosylate is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib tosylate exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib tosylate can be used for haematological malignancies reseach. 

Verwenden

RP 5264 is a novel PI3K inhibitor that enhances Brentuximab Vedotin-induced lymphoma cell death.

Trademarks

Ukonig

Umbralisib Upstream-Materialien And Downstream Produkte

Upstream-Materialien

1532533-34-8 1532533-36-0 1532533-31-5 3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2-(3-Fluoro-4-isopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 1300582-10-8 1532533-32-6 4-Bromo-2-fluorophenol 2-(4'-BROMO-2'-FLUOROPHENOXY)PROPANE 1-(5-Fluoro-2-hydroxyphenyl)-2-(3-fluorophenyl)ethanone TGR-1202 (R-enantiomer) 3-Fluorphenylessigsure 4-Fluoranisol

Downstream Produkte

Umbralisib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 78)Lieferanten
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Shanghai Huici Pharmaceutical Technology Co., LTD 		+8618917134367
 lixing@pharmahuici.com China 133 58
Shanghai Huici Pharmaceutical Technology Co., LTD 		+8618917134367
 lixing@pharmahuici.com China 133 58
  • TGR-1202
  • RP-5264
  • RP-5264 TGR-1202
  • TGR1205
  • Umbralisib
  • Umbralisib (TGR-1202)
  • 4H-1-Benzopyran-4-one, 2-[(1S)-1-[4-amino-3-[3-fluoro-4-(1-methylethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)-
  • (S)-2-(1-(4-AMINO-3-(3-FLUORO-4-ISOPROPOXYPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL)ETHYL)-6-FLUORO-3-(3-FLUOROPHENYL)-4H-CHROMEN-4-ONE
  • RP5264;UMBRALISIB
  • CS-2443
  • RP5264; TGR1202; TGR 1202; RP-5264; RP 5264
  • TGR-1202(Umbralisib)
  • inhibit,RP-5264,lymphocytic leukemia,lymphoma,CLL T cells,Inhibitor,Umbralisib,haematological malignancies,cancer,orally active,PI3K,RP 5264,Phosphoinositide 3-kinase,Casein Kinase
  • 1532533-67-7
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